EFFECTS OF THYMOQUINONE, ZEOLITE AND PLATELET RICH PLASMA ON THE HEALING OF ISCHEMIC COLONIC ANASTOMOSIS

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dc.contributor.authorPehlivanlı, Faruk
dc.contributor.authorKaraca, Gökhan
dc.contributor.authorAydın, Oktay
dc.contributor.authorAltunkaya, Canan
dc.contributor.authorŞahiner, İbrahim Tayfun
dc.contributor.authorÖzden, Hüseyin
dc.contributor.authorUzun, Hafize
dc.date.accessioned2025-01-21T16:17:15Z
dc.date.available2025-01-21T16:17:15Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: Anastomosis on ischemic intestines is a problematicissue in daily surgical routine. In this study, we investigated thepotential effects of thymoquinone, zeolite and platelet rich plasma.Material and Methods: Fifty rats were divided into five groups.In the sham group all rats underwent colonic anastomosis withoutany ischemic insult. Colonic anastomosis was performed aftermesenteric ischemia was induced by clamping the superiormesenteric artery in other study groups. In the control group, nomedication was given to the rats after ishemic anastomosis. InZeolite group and thymoquinone group, Zeolite and thymoquinonewere applied locally on the anastomosis. In the platelet richplasma group, platelet rich plasma was applied locally on theanastomosis. All the rats were sacrified on the 10th day. Blood andtissue samples were retrieved.Results: Hydroxyproline levels were not different between thegroups. Bursting pressure was higher in the thymoquinone groupthan the control group. Reepithelization was higher than thezeolite group in the sham and thymoquinone groups. TNF-? andIL 1? levels were significantly higher in the sham group than allthe other groups. TNF-? and IL 1? levels were also significantlyhigher in the thymoquinone, zeolite and platelet rich plasmagroups than the control group and higher in the thymoquinonegroup than the zeolite and platelet rich plasma groups.Inflammation and ischemic necrosis levels were not differentbetween the groups.Conclusion: Our data is suggesting that thymoquinone andplatelet rich plasma have positive effects on ischemic anastomosishealing, while thymoquinone has the best results.
dc.identifier.endpage72
dc.identifier.issn2148-9645
dc.identifier.issue1
dc.identifier.startpage65
dc.identifier.trdizinid414860
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/414860
dc.identifier.urihttps://hdl.handle.net/20.500.12587/22599
dc.identifier.volume21
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofKırıkkale Üniversitesi Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectGenel ve Dahili Tıp
dc.subjectPatoloji
dc.subjectHücre Biyolojisi
dc.subjectCerrahi
dc.titleEFFECTS OF THYMOQUINONE, ZEOLITE AND PLATELET RICH PLASMA ON THE HEALING OF ISCHEMIC COLONIC ANASTOMOSIS
dc.typeArticle

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