Differential expression of P63, P27, P57, Ki-67, and CD146 in hydropic and molar pregnancies

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dc.contributor.authorBalci, Mahi
dc.contributor.authorOzdemir, Gulhan
dc.date.accessioned2025-01-21T16:27:16Z
dc.date.available2025-01-21T16:27:16Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractOBJECTIVE: To investigate the expressions of immunohistochemical markers P63, P27, P57, Ki-67 and CD146 in hydropic and molar specimens in order to explore their role in the pathogenesis of molar gestations. METHODS: The retrospective study was conducted at the Kırıkkale Medical University, Turkey, and comprised data from 2011 to 2018 related to patients with a definitive pathological diagnosis of hydropic abortus, complete hydatidiform moles and partial hydatidiform moles. Immunoreactivity using antibodies against P63, P27, P57, Ki-67 and CD146 was scored by evaluating the percentage of distinctly stained cells. Data was analysed using SPSS 15. RESULTS: Of the 37 specimens, 10(27%) were hydropic abortus, 17(46%) partial hydatidiform moles and 10(27%) complete hydatidiform moles. Patients with complete hydatidiform moles severe cytologic atypia in CD146-positive extravillous trophoblastic column and florid syncytiotrophoblast proliferation. P57 immunostaining was negative in 9(90%) patients with complete hydatidiform moles, whereas all patients in the two other groups showed positive immunostaining, and they also showed P63 and Ki-67 overexpression in cytotrophoblasts. P27 was expressed in differentiated, non-dividing syncytiotrophoblasts but did not yield any diagnostic aid. CONCLUSIONS: The proliferative activity location varied between molar and nonmolar pregnancies.
dc.identifier.doi10.47391/JPMA.798
dc.identifier.endpage800
dc.identifier.issn0030-9982
dc.identifier.issue3
dc.identifier.pmid34057923
dc.identifier.scopus2-s2.0-85107322930
dc.identifier.scopusqualityQ3
dc.identifier.startpage796
dc.identifier.urihttps://doi.org/10.47391/JPMA.798
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23311
dc.identifier.volume71
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNLM (Medline)
dc.relation.ispartofJPMA. The Journal of the Pakistan Medical Association
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectHydatidiform mole, Hydropic abortion, P63, P27, P57, Ki-67, CD146.
dc.titleDifferential expression of P63, P27, P57, Ki-67, and CD146 in hydropic and molar pregnancies
dc.typeArticle

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