The Effect of Repeated Doses of Intermittent Ketamine on Erythrocyte Deformability in Infant Rats

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dc.authoridArslan, Mustafa/0000-0003-4882-5063
dc.authoridKucuk, Aysegul/0000-0001-9316-9574
dc.contributor.authorKasikara, Hulya
dc.contributor.authorComu, Faruk Metin
dc.contributor.authorKucuk, Aysegul
dc.contributor.authorOzturk, Levent
dc.contributor.authorArslan, Mustafa
dc.date.accessioned2025-01-21T16:45:20Z
dc.date.available2025-01-21T16:45:20Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim: Blood rheology, which is affected by many factors, is also known to be affected by drugs used for anesthesia. Therefore, we aimed to investigate the effects of 21-day ketamine administration on erythrocyte deformability in 3-week-old infant rats Methods: Twelve 12 week old Wistar Albino male infant rats were randomly divided into two groups. Ketamine group (K), n:6, 50 mg/kg ketamine was administered intraperitoneally at the same time daily for 21 days. Saline group (S), n.6, 50 mg/kg normal saline was administered intraperitoneally at the same time daily for 21 days. After 21 days of administration, all rats were euthanized by intraperitoneal ketamine (100 mg/kg) and taken blood from abdominal aorta. Erythrocytes were obtained from heparinized blood samples. Deformability measurements were performed on erythrocyte suspensions in phosphate buffered saline. For the measurement of erythrocyte deformability, a constant flow filtrometer system was used and the relative resistance was calculated. Results: Ketamine administration was found to increase relative resistance. The erythrocyte deformability index was significantly higher in the ketamine group compared to the saline group (p:0.006). Conclusion: We found that long-term repeated ketamine administration negatively affected erythrocyte deformability. In our study, we think that the results obtained in daily anesthesia will be a guide for repeated administration of ketamine, especially in radiation oncology. However, these findings should be supported by clinical and experimental studies in more detailed and large series.
dc.identifier.doi10.12996/gmj.2022.73
dc.identifier.endpage324
dc.identifier.issn2147-2092
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85140336666
dc.identifier.scopusqualityQ4
dc.identifier.startpage322
dc.identifier.urihttps://doi.org/10.12996/gmj.2022.73
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25613
dc.identifier.volume33
dc.identifier.wosWOS:000863207700001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherGazi Univ, Fac Med
dc.relation.ispartofGazi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectKetamine; repeated administration; infant rat; erythrocyte deformability
dc.titleThe Effect of Repeated Doses of Intermittent Ketamine on Erythrocyte Deformability in Infant Rats
dc.typeArticle

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