Long-term predictive value of cardiac biomarkers in patients with COVID-19 infection

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dc.authoridINANC, IBRAHIM HALIL/0000-0003-4046-6748
dc.authoridpolat, esra/0000-0002-2330-2816
dc.contributor.authorSabanoglu, C.
dc.contributor.authorInanc, I. H.
dc.contributor.authorPolat, E.
dc.contributor.authorPeker, S. A.
dc.date.accessioned2025-01-21T16:42:23Z
dc.date.available2025-01-21T16:42:23Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractOBJECTIVE: Several studies have investigated the association between cardiac biomarkers and short-term prognosis in the COVID-19 infection. However, the data on the pre-dictive value of cardiac biomarkers to predict long-term prognosis in COVID-19 infection are limited. We aimed at determining the relationship between N-terminal brain-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin I (hs-TnI) as cardiac biomarkers and in-hospital/ long-term outcomes in COVID-19 infection.PATIENTS AND METHODS: The study included a total of 916 patients with confirmed COVID-19 infection. The primary outcome was in-hospital and 1-year mortality. The secondary outcome was intensive care need at admission or the need to be transferred to the intensive care unit later on.RESULTS: The study included 498 (54.4%) males and 418 (45.6%) females with a mean age of 55.1 & PLUSMN;18.5 years. The patients with known heart failure (HF), COVID-19-related HF, acute renal failure (ARF), chronic kidney disease (CKD), diabetes mellitus, hypertension, coronary artery dis-ease (CAD), chronic obstructive pulmonary dis-ease (COPD)/asthma, high CO-RADS score (& GE; 4), lower EF, higher hs-TnI, and NT-proBNP levels had increased in-hospital and 1-year mortality. After multivariate analysis, NT-proBNP, hs-TnI, CKD, ARF, diabetes mellitus, and CAD were independent predictors of in-hospital and 1-year mortali-ty. After ROC analysis, NT-proBNP cut-off levels of 1022.50 (sensitivity 87.5%, specificity 87.1%) and 1008 (sensitivity 88.6%, specificity 88.0%) were found to predict in-hospital and 1-year mortality, respectively. Hs-TnI cut-off levels of 49.6 (sensitivity 88.6%, specificity 88.9%) and 34.10 (sensitivity 83.8%, specificity 84.1%) were found to predict in-hospital and 1-year mortality, respectively.CONCLUSIONS: The current study suggests that NT-proBNP and hs-TnI can be used as valuable cardiac biomarkers to predict short-term and long-term parameters in COVID-19 infection.
dc.identifier.endpage6403
dc.identifier.issn1128-3602
dc.identifier.issue17
dc.identifier.pmid36111943
dc.identifier.startpage6396
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25066
dc.identifier.volume26
dc.identifier.wosWOS:000865414400017
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectCardiac biomarkers; High-sensitivity cardiac troponin I; hs-TnI; N-terminal brain-type natriuretic peptide; NT-proB-NP; COVID-19
dc.titleLong-term predictive value of cardiac biomarkers in patients with COVID-19 infection
dc.typeArticle

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