The first step of patient-specific design calvarial implant: A quantitative analysis of fresh parietal bones

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dc.contributor.authorGovsa, Figen
dc.contributor.authorCelik, Servet
dc.contributor.authorTurhan, Tuncer
dc.contributor.authorSahin, Volkan
dc.contributor.authorCelik, Meral
dc.contributor.authorSahin, Korhan
dc.contributor.authorKazak, Zuhal
dc.date.accessioned2020-06-25T18:29:24Z
dc.date.available2020-06-25T18:29:24Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.descriptioncelik, servet/0000-0002-1102-4417
dc.description.abstractBackgroundAccurate knowledge of the fracture of cranial bone can provide insight into the prevention of skull fracture injuries and help aid the design of energy-absorbing head protection systems and safety helmets. When cranial bone needs to be removed or is lost, subsequent reconstruction of the defect is necessary to protect the underlying brain, or correct esthetic deformities, or both. Ideal reconstruction of defected bone is possible utilizing a biocompatible implant with a bone-like design individualized for the specific patient. The purpose of this study is to investigate the anatomical and mechanical characteristics of fresh frozen human parietal bones and determine compliance of polylactic acid-based personalized three-dimensional implants in terms of mechanical properties in order to replace such defective bones.MethodsParietal bone specimens were extracted from 19 fresh frozen cadavers. Morphological parameters of individual bone specimens were measured using Image J software. Three-point bend tests were performed to extract Young's modulus and tensile strength of the specimens from the measured force and displacement data by modeling the bone specimens as curved linear elastic beams. Also, three-point bend tests were performed to polylactic acid-based three-dimensional replicas mimicking geometry of the bone specimens in order to determine whether the material's Young's modulus and tensile strength properties comply with parietal bones.ResultsEntire fresh parietal specimens were observed to be comprised of a three-layered structure: external layers consisting of compact, high-density cortical bone and the central layer consisting of low-density, irregularly porous bone structure. Mean thickness of three-layered structure was 6.251.46mm. Mean Young's modulus and tensile strength of the specimens were 1.401.34GPa and 44.56 +/- 21.94MPa, respectively where no statistically significant differences among genders were detected (p>0.05). Mean Young's modulus and tensile strength of the polylactic acid-based three-dimensional implants mimicking geometry of the bone specimens were 1.8 +/- 0.7GPa and 72.8 +/- 2.5MPa, respectively.ConclusionsPolylactic acid-based three-dimensional implants can be considered as acceptable candidates for temporary replacement of parietal defects in terms of mechanical properties.Level of Evidence: Not ratable.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00238-018-1411-6
dc.identifier.endpage520en_US
dc.identifier.issn0930-343X
dc.identifier.issn1435-0130
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85045831571
dc.identifier.scopusqualityQ3
dc.identifier.startpage511en_US
dc.identifier.urihttps://doi.org/10.1007/s00238-018-1411-6
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7296
dc.identifier.volume41en_US
dc.identifier.wosWOS:000445241400004
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal Of Plastic Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectThree-dimensional cranial implanten_US
dc.subjectDigital designen_US
dc.subjectCustom-made skull prosthesisen_US
dc.subjectSkull defectsen_US
dc.subjectPatient-specific implanten_US
dc.subjectParietal boneen_US
dc.subjectPolylactic acid-based implanten_US
dc.titleThe first step of patient-specific design calvarial implant: A quantitative analysis of fresh parietal bonesen_US
dc.typeArticle

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