Skull base osteomyelitis: Comprehensive analysis and a new clinicoradiological classification system

Basit Öğe Kaydı
dc.authoridPamuk, Erim/0000-0002-8813-0357
dc.contributor.authorOzer, Furkan
dc.contributor.authorPamuk, Ahmet Erim
dc.contributor.authorAtay, Gamze
dc.contributor.authorParlak, Safak
dc.contributor.authorYucel, Taskun
dc.date.accessioned2025-01-21T16:44:24Z
dc.date.available2025-01-21T16:44:24Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: Skull baseosteomyelitis (SBO) is a rare phenomenon that typically occurs in diabetic or immunocompromised patients, causing significant morbidity and mortality. This study aimed to analyze a single institution's treatment results in SBO patients and propose anew integrated clinicoradiological classification system. Methods: The medical records of 32 SBO patients that were treated at a tertiary care center between 2006 and 2017 were retrospectively reviewed. A scoring system based on anatomical involvement according to MRI was created. Subsequently, the scoring system was integrated with cranial nerve dysfunction status and a clinical grading system (CGS) was proposed. Results: Among the 32 patients, 78.1% were diabetic and 63% had cranial nerve dysfunction at presentation. Bone erosion based on CT was greater in the patients without regression (P = 0.046). The regression rate decreased from clinical grade (CG)1 to CG3 (P = 0.029). Duration of hospitalization increased as CG increased (P = 0.047). Surgery had no effect on regression status at the time of discharge (P = 0.41). The 1-year, 2-year, and 5-year overall survival rates were 82.2%, 70.8%, and 45.8%, respectively. CG was significantly correlated with overall survival but not with disease-specific survival (log-rank; P = 0.017, P = 0.362, respectively). Conclusion: SBO continues to pose a challenge to clinicians, and causes significant morbidity and mortality. The proposed new classification system can be an option for grouping SBO patients according to clinical and radiological findings, helping clinicians estimate prognosis. (C) 2021 Oto-Rhino-Laryngological Society of Japan Inc. Published by Elsevier B.V. All rights reserved.
dc.identifier.doi10.1016/j.anl.2021.02.006
dc.identifier.endpage1006
dc.identifier.issn0385-8146
dc.identifier.issn1879-1476
dc.identifier.issue5
dc.identifier.pmid33640201
dc.identifier.startpage999
dc.identifier.urihttps://doi.org/10.1016/j.anl.2021.02.006
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25452
dc.identifier.volume48
dc.identifier.wosWOS:000663123800029
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier Sci Ltd
dc.relation.ispartofAuris Nasus Larynx
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectSkull base osteomyelitis (SBO); Skull base; External ear; Classification; Magnetic resonance imaging; CT scan
dc.titleSkull base osteomyelitis: Comprehensive analysis and a new clinicoradiological classification system
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu