Preparation, Characterization, and Salicylic Acid Release Behavior of Chitosan/Poly(vinyl alcohol) Blend Microspheres
Yükleniyor...
Tarih
2009
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
John Wiley & Sons Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Blend microspheres of chitosan (CS) with poly(vinyl alcohol) (PVA) were prepared as candidates for oral delivery system. CS/PVA microspheres containing salicylic acid (SA), as a model drug, were obtained using the coacervation-phase separation method, induced by addition of a nonsolvent (sodium hydroxide solution) and then crosslinked with glutaraldeyde (GA) as a crosslinking agent. The microspheres were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry (DSC), and scanning electron microscopy. Percentage entrapment efficiency, particle size, and equilibrium swelling degree of the microsphere formulations were determined. The results indicated that these parameters were changed by preparation conditions of the microspheres. Effects of variables such as CS/PVA ratio, pH, crosslinker concentration, and drug/polymer (d/p) ratio on the release of SA were studied at three different pH values (1.2, 6.8, and 7.4) at 37 degrees C. It was observed that SA release from the microspheres increased with decreasing CS/PVA ratio and d/p ratio whereas it decreased with the increase in the extent of crosslinking. It may also be noted that drug release Was Much higher at pH 1.2 than that of at pH 6.8 and 7.4. The highest SA release percentage was obtained as 100% for the microspheres prepared with PVA/CS ratio of 1/2, d/p ratio of 1/2, exposure time to GA of 5 min, and concentration of GA 1.5%, at the end of 6 h. (C) 2008 Wiley Periodicals, Inc. J Appl Polym Sci 111: 2731-2740, 2009
Açıklama
Anahtar Kelimeler
controlled release, drug delivery systems, salicylic acid, hydrophilic polymers
Kaynak
Journal Of Applied Polymer Science
WoS Q Değeri
Q2
Scopus Q Değeri
Cilt
111
Sayı
6
Künye
closedAccess
