Preparation, Characterization, and Salicylic Acid Release Behavior of Chitosan/Poly(vinyl alcohol) Blend Microspheres

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dc.contributor.authorŞanlı, Oya
dc.contributor.authorKaraca, İlker
dc.contributor.authorIşıklan, Nuran
dc.date.accessioned2020-06-25T17:48:32Z
dc.date.available2020-06-25T17:48:32Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBlend microspheres of chitosan (CS) with poly(vinyl alcohol) (PVA) were prepared as candidates for oral delivery system. CS/PVA microspheres containing salicylic acid (SA), as a model drug, were obtained using the coacervation-phase separation method, induced by addition of a nonsolvent (sodium hydroxide solution) and then crosslinked with glutaraldeyde (GA) as a crosslinking agent. The microspheres were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry (DSC), and scanning electron microscopy. Percentage entrapment efficiency, particle size, and equilibrium swelling degree of the microsphere formulations were determined. The results indicated that these parameters were changed by preparation conditions of the microspheres. Effects of variables such as CS/PVA ratio, pH, crosslinker concentration, and drug/polymer (d/p) ratio on the release of SA were studied at three different pH values (1.2, 6.8, and 7.4) at 37 degrees C. It was observed that SA release from the microspheres increased with decreasing CS/PVA ratio and d/p ratio whereas it decreased with the increase in the extent of crosslinking. It may also be noted that drug release Was Much higher at pH 1.2 than that of at pH 6.8 and 7.4. The highest SA release percentage was obtained as 100% for the microspheres prepared with PVA/CS ratio of 1/2, d/p ratio of 1/2, exposure time to GA of 5 min, and concentration of GA 1.5%, at the end of 6 h. (C) 2008 Wiley Periodicals, Inc. J Appl Polym Sci 111: 2731-2740, 2009en_US
dc.description.sponsorshipGazi University Scientific Research FoundationGazi Universityen_US
dc.description.sponsorshipContract grant sponsors: Gazi University Scientific Research Foundation.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1002/app.29319
dc.identifier.endpage2740en_US
dc.identifier.issn0021-8995
dc.identifier.issue6en_US
dc.identifier.startpage2731en_US
dc.identifier.urihttps://doi.org/10.1002/app.29319
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4486
dc.identifier.volume111en_US
dc.identifier.wosWOS:000262685000010
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherJohn Wiley & Sons Incen_US
dc.relation.ispartofJournal Of Applied Polymer Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectcontrolled releaseen_US
dc.subjectdrug delivery systemsen_US
dc.subjectsalicylic aciden_US
dc.subjecthydrophilic polymersen_US
dc.titlePreparation, Characterization, and Salicylic Acid Release Behavior of Chitosan/Poly(vinyl alcohol) Blend Microspheresen_US
dc.typeArticle

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