Identification of intestinal M cells in isolated lymphoid follicles and Peyer's patches of the Angora rabbit

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dc.contributor.authorBeyaz, Feyzullah
dc.contributor.authorErgün, Emel
dc.contributor.authorBayraktaroğlu, Alev G.
dc.contributor.authorErgün, Levent
dc.date.accessioned2020-06-25T17:49:14Z
dc.date.available2020-06-25T17:49:14Z
dc.date.issued2010
dc.departmentKırıkkale Üniversitesi
dc.descriptionBeyaz, Feyzullah/0000-0002-9365-4104
dc.description.abstractThe presence, distribution, and localization of M cells in isolated lymphoid follicles (ILF) and in follicle-associated epithelia (FAE) covering Peyer's patches (PP) in Angora rabbits were investigated by immunohistochemistry and electron microscopy. Although PP could macroscopically be identified along the length of the mucosal and serosal surfaces of jejunum and ileum, the presence of ILF could only be located microscopically. Typical M cells in FAE were detected within the periphery of the dome regions of the PP, and immature columnar M cells in the FAE resided in the vicinity of the crypts. M cells in the FAE of both ILF and PP showed vimentin-positive reaction. M cells in the FAE of ILF were morphologically similar to the immature M cells found in the FAE of PP. Typical mature M cells were also observed in the FAE of a few ILF. In contrast to FAE of PP, numerous goblet cells were observed in the FAE of many ILF. Moreover, among intestinal villi, we noticed villi-like solitary lymphoid structures that showed abundant lymphocytes in their lamina propria and that were surrounded with vimentin-positive cells and goblet cells. Thus, the occurrence of copious immature M cells and goblet cells, in addition to the detection of villi-like solitary lymphoid structures full of lymphocytes in the FAE of many ILF, indicate that ILF do not complete their immunological maturation in contrast to PP. Various antigenic stimulations conceivably induce the formation and maturation of ILF along the length of the small intestine. The morphological resemblance between ILF M cells and PP M cells suggests that these two types of cells perform similar or the same immunological functions.en_US
dc.description.sponsorshipScientific Research Projects Commission of Erciyes UniversityErciyes University [EUBAP VA-03-11]; Scientific Research Coordination Department of Kirikkale UniversityKirikkale University [2007-24]en_US
dc.description.sponsorshipThe chemical materials used in this study were supplied under projects financially supported by the Scientific Research Projects Commission of Erciyes University (EUBAP VA-03-11) and the Scientific Research Coordination Department of Kirikkale University (2007-24).en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00441-010-1005-5
dc.identifier.endpage427en_US
dc.identifier.issn0302-766X
dc.identifier.issn1432-0878
dc.identifier.issue3en_US
dc.identifier.pmid20596875
dc.identifier.startpage417en_US
dc.identifier.urihttps://doi.org/10.1007/s00441-010-1005-5
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4672
dc.identifier.volume341en_US
dc.identifier.wosWOS:000281670800008
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofCell And Tissue Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIntestineen_US
dc.subjectIsolated lymphoid folliclesen_US
dc.subjectM cellsen_US
dc.subjectPeyer's patchesen_US
dc.subjectVimentinen_US
dc.subjectRabbit (Angora)en_US
dc.titleIdentification of intestinal M cells in isolated lymphoid follicles and Peyer's patches of the Angora rabbiten_US
dc.typeArticle

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