Evaluation of Erythrocyte Deformability in Experimentally Induced Osteoporosis in Male Rats and the Effects of Vitamin C Supplementation on Erythrocyte Deformability and Bone Mineral Density

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dc.contributor.authorArslan, Mustafa
dc.contributor.authorÇomu, Faruk Metin
dc.contributor.authorKeleş, Işık
dc.contributor.authorArslan, Ayşe
dc.date.accessioned2020-06-25T18:06:33Z
dc.date.available2020-06-25T18:06:33Z
dc.date.issued2012
dc.departmentKırıkkale Üniversitesi
dc.descriptionArslan, Mustafa/0000-0003-4882-5063
dc.description.abstractObjective: Male osteoporosis (OP) is a major problem in clinical medicine, but has gained less interest than female OP The mechanisms of male OP have not been explained well and are not clear yet. It is suggested that there is a role for oxidative stress in the pathophysiology of many diseases, one of them being OR In this study, we investigated the effect of orchiectomy on bone mineral density (BMD), the level of antioxidant enzymes, lipid peroxidation, and erythrocyte deformability in rats and the effect of vitamin C supplementation on the possible changes in these parameters. Metarials and Methods: A total of 20 male Wistar albino rats were randomized into three groups: controls (C, n=6), orchiectomized rats (O, n=7) and orchiectomized rats receiving vitamin C supplementation (OVC, n=7). The concentration of superoxide-dismutase (SOD) and malondialdehyde (MDA) in bone tissue homogenates were measured to assess the oxidative stress. Erythrocyte deformability was measured using erythrocyte suspensions at 5% hematocrit in phosphate buffered saline. Results: When oxidant/antioxidant parameters were compared between the groups, SOD activity in bone tissue was significantly higher in group 0 than in group OVC (p=0.032). Erythrocyte deformability was significantly higher in group O than in group C and OVC (p=0.003, p=0.018, respectively). Conclusion: Erythrocyte deformability may show negative variations, suggesting a causative role in disruption of blood flow and tissue perfusion, which also affect bone metabolism negatively Vitamin C supplementation seems to reverse those negative effects of variations in erythrocyte deformability. However, our preliminary results need to be confirmed in wider serious of experimental and clinical trials. Turk J Phys Med Rehab 2012;58:121-5.en_US
dc.identifier.citationArslan, M.& Comu, F. M. & Keles, I. & Arslan, A. (2012). Evaluation of Erythrocyte Deformability in Experimentally Induced Osteoporosis in Male Rats and the Effects of Vitamin C Supplementation on Erythrocyte Deformability and Bone Mineral Density. Turkiye Fiziksel Tip ve Rehabilitasyon Dergisi. 58(2), 121-125. 10.4274/tftr.68725.en_US
dc.identifier.doi10.4274/tftr.68725
dc.identifier.endpage125en_US
dc.identifier.issn1302-0234
dc.identifier.issn1308-6316
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84863996870
dc.identifier.scopusqualityN/A
dc.identifier.startpage121en_US
dc.identifier.urihttps://doi.org/10.4274/tftr.68725
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5251
dc.identifier.volume58en_US
dc.identifier.wosWOS:000306640000010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isotr
dc.publisherBaycinar Medical Publ-Baycinar Tibbi Yayinciliken_US
dc.relation.ispartofTurkiye Fiziksel Tip Ve Rehabilitasyon Dergisi-Turkish Journal Of Physical Medicine And Rehabilitation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectOrchiectomyen_US
dc.subjectosteoporosisen_US
dc.subjecterythrocyte deformabilityen_US
dc.subjectsuperoxide dismutaseen_US
dc.subjectmalondialdehydeen_US
dc.titleEvaluation of Erythrocyte Deformability in Experimentally Induced Osteoporosis in Male Rats and the Effects of Vitamin C Supplementation on Erythrocyte Deformability and Bone Mineral Densityen_US
dc.typeArticle

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