The long-term efficacy and safety of botulinum toxin in refractory chronic tension-type headache

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dc.contributor.authorErdemoglu, Ali Kemal
dc.contributor.authorVarlibaş, Ayhan
dc.date.accessioned2020-06-25T15:13:50Z
dc.date.available2020-06-25T15:13:50Z
dc.date.issued2007
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe objective of this study was to investigate the long-term efficacy and safety of botulinum toxin type-A (BoNT-A) for refractory chronic tension-type headache (CTTH). An open-label, prospective study was carried out in the Department of Neurology of Kirikkale University on 28 patients (8 males, 20 females), mean age 35.6 years, diagnosed with moderate/severe CTTH refractory to preventive medications. Each patient received BoNT-A injections once in pericranial muscles. Efficacy and safety data were analysed for 28 refractory CTTH patients who were receiving concomitant headache prophylactic medications at baseline and during the study. The main outcome parameters were reduction of headache frequency and intensity over 1 year. Both parameters were significantly decreased (p<0.05) by the end of the study. Sixty-four percent of patients reported complete headache relief at the final visit, compared to 7% CTTH persisted. BoNT-A also resulted in significant reductions in analgesic consumption (p<0.05). Adverse effects were transient and local. BoNT-A was found to be an effective and safe treatment for refractory CTTH patients with concomitant headache prophylactic medications, resulting in significant reductions in headache frequency, intensity and analgesic consumption which persisted up to 1 year. © Springer-Verlag Italia 2007.en_US
dc.description.sponsorshipAllerganen_US
dc.description.sponsorshipInternational Headache Society, Rome, Italy, 13–16 September 2003. This study was supported by an unrestricted grant from Allergan Inc, Irvine, CA, USA.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s10194-007-0414-7
dc.identifier.endpage300en_US
dc.identifier.issn11292369
dc.identifier.issue5en_US
dc.identifier.pmid17955170
dc.identifier.scopus2-s2.0-36749030140
dc.identifier.scopusqualityQ1
dc.identifier.startpage294en_US
dc.identifier.urihttps://doi.org/10.1007/s10194-007-0414-7
dc.identifier.urihttps://hdl.handle.net/20.500.12587/1944
dc.identifier.volume8en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofJournal of Headache and Pain
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBotulinum toxin type-A (BoNT-A)en_US
dc.subjectChronic tension-type headache (CTTH)en_US
dc.subjectHeadache frequencyen_US
dc.subjectHeadache intensityen_US
dc.subjectRefractoryen_US
dc.subjectTreatmenten_US
dc.titleThe long-term efficacy and safety of botulinum toxin in refractory chronic tension-type headacheen_US
dc.typeArticle

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