The impact of percutaneous left atrial appendage closure on left ventricular diastolic function and natriuretic peptide levels

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dc.authoridOto, Sibel/0000-0003-0171-4200
dc.authoridINANC, IBRAHIM HALIL/0000-0003-4046-6748
dc.contributor.authorSabanoglu, C.
dc.contributor.authorOkutucu, S.
dc.contributor.authorCnanc, I. Halil
dc.contributor.authorYorgun, H.
dc.contributor.authorAytemir, K.
dc.contributor.authorOto, A.
dc.date.accessioned2025-01-21T16:45:38Z
dc.date.available2025-01-21T16:45:38Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractOBJECTIVE: Although the efficacy and safety of left atrial (LA) appendage (LAA) closure in patients with atrial fibrillation (AF) have been well documented in randomized controlled trials and real-world experience, there are limited data in the literature about the impact of LAA closure on diastolic functions. The study aimed to examine the impact of LAA closure on diastolic function and natriuretic peptide levels in patients with AF. PATIENTS AND METHODS: Twelve non-valvular AF patients with high risk for developing cardioembolic stroke and contraindications to warfarin underwent LAA occlusion with the WATCHMAN device (Atritech Inc., Plymouth, MN, USA). B-type natriuretic peptide levels and detailed diastolic parameters (mitral inflow velocities, deceleration time (DT), flow propagation velocity (Vp), isovolumetric relaxation time (IVRT), mitral annular e', TE-e', IVRT/TE-e', EJVp, E/e', pulmonary vein flow parameters consisting of S. D, and S/D) were evaluated at baseline and 45 days after LAA closure. RESULTS: The median age of the patients was 69 (54-78) years and 75% (n: 9) of them were male. All patients completed forty-five days of follow-up. Compared to the baseline values, E/Vp ratio and BNP levels (1.95 (0.94-3.32) vs. 2.37 (1.09-4.46), p= 0.015: 290.0 (90-1271) pg/mI vs. 322.00 (106-1635) pg/ml, p=0.018. respectively) increased, and pulmonary vein S wave and S/D ratio (0.67 (0.33-0.92) vs. 0.38 (0.23-0.91) m/sec, p=0.048: 1.62 (0.865.75) vs. 1.33 (0.11-3.35), p=0.019. respectively) decreased after LAA closure. CONCLUSIONS: In the present study, we demonstrated that patients with AF have shown impaired diastolic functions and elevated BNP levels after the percutaneous closure of the LAA.
dc.identifier.endpage7424
dc.identifier.issn1128-3602
dc.identifier.issue23
dc.identifier.pmid34919244
dc.identifier.startpage7418
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25687
dc.identifier.volume25
dc.identifier.wosWOS:000731756100030
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectPercutaneous left atrial appendage closure; Ventricular diastolic dysfunction; Natriuretic peptide
dc.titleThe impact of percutaneous left atrial appendage closure on left ventricular diastolic function and natriuretic peptide levels
dc.typeArticle

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