LIPID PEROXIDATION AND THE ANTIOXIDANT CAPACITY OF DIALYSIS PATIENTS: The Effects of a Single Hemodialysis Session with Different Dialysis Membranes
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Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Gazi Univ, Fac Med
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: To estimate lipid peroxidation and the antioxidant defense capacity of dialysis patients and the effects of different types of dialysis membranes on these parameters. Methods: Fifty-four dialysis patients and 30 healthy controls were included in this study. Ten of the dialysis patients were on continuous ambulatory peritoneal dialysis treatment and the rest were on hemodialysis with either polycarbonate membrane (n=10) or hemophan membrane (n=34). Polycarbonate membranes were switched with a vitamin E-coated dialyzer in the subsequent dialysis session. Total antioxidant status and malondialdehyde levels were studied to determine the antioxidant defense capacity and lipid peroxidation, respectively, before and after the dialysis session. Results: Plasma total antioxidant status levels were lower (1.51 +/- 0.2 mmol/l vs. 1.75 +/- 0.20 mmol/l p<0.05) and malondialdehyde levels were higher (2.2 +/- 1.17 nmol/ml vs. 0.60 +/- 0.20 nmol/ml p<0.05) in all dialysis patients compared to the control group. After one hemodialysis session, there were no significant alterations in parameters for either type of dialysis membrane. Conclusion: All dialysis patients have an increased oxidative status. A single hemodialysis session with different dialysis membranes does not seem to significantly change the oxidant or antioxidant levels.
Açıklama
Anahtar Kelimeler
antioxidant status; malondialdehyde; hemodialysis; peritoneal dialysis
Kaynak
Gazi Medical Journal
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
19
Sayı
2
