Temperature-responsive alginate-g-poly(N,N-diethylacrylamide) copolymer: Synthesis, characterization, and swelling behavior

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dc.contributor.authorIsiklan, Nuran
dc.contributor.authorAltinisik, Zeynep
dc.date.accessioned2020-06-25T18:29:22Z
dc.date.available2020-06-25T18:29:22Z
dc.date.issued2018
dc.departmentKırıkkale Üniversitesi
dc.description.abstractTemperature-responsive polymers have recently gained importance due to their applications in drug delivery. Herein, temperature-responsive graft copolymer (Alg-g-PDEAAm) of alginate and N,N-diethylacrylamide was synthesized by microwave-assisted copolymerization using potassium persulfate/N,N,N,N-tetramethylethylenediamine initiator system. The reaction conditions for the best grafting (331%) have been optimized by changing microwave irradiation time, temperature, N,N-diethylacrylamide, and alginate concentrations. The spectroscopic characteristic, thermal properties, and surface morphology of the copolymers were investigated by FTIR, H-1-NMR, DSC/TGA, XRD, gel permeation chromatography, and SEM. Furthermore, low critical solution temperatures of Alg-g-PDEAAm copolymers were detected by UV spectroscopy. Swelling ratio of graft microspheres was carried out at 25, 32, and 37 degrees C, and microspheres were found exhibiting temperature-responsive property. Cytotoxicity test indicated the Alg-g-PDEAAm copolymer and its microsphere were biocompatible. Therefore, based on the results the synthesized temperature-responsive copolymer could be considered as a promising biomaterial. (c) 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018, 135, 46688.en_US
dc.description.sponsorshipTUBITAKTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113Z271]en_US
dc.description.sponsorshipThis study is financially supported by TUBITAK with the grant number of 113Z271.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1002/app.46688
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.issue38en_US
dc.identifier.scopus2-s2.0-85053626657
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1002/app.46688
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7271
dc.identifier.volume135en_US
dc.identifier.wosWOS:000445503300008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Applied Polymer Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbiocompatibilityen_US
dc.subjectgraftingen_US
dc.subjectpolysaccharidesen_US
dc.subjectstimuli-sensitive polymersen_US
dc.subjectthermal propertiesen_US
dc.titleTemperature-responsive alginate-g-poly(N,N-diethylacrylamide) copolymer: Synthesis, characterization, and swelling behavioren_US
dc.typeArticle

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