The Effect of Treatment on Endothelin-1 Concentration and Mean Arterial Pressure in Preeclampsia and Eclampsia

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dc.contributor.authorSağsöz Nevin
dc.contributor.authorKüçüközkan Tuncay
dc.date.accessioned2020-06-25T15:13:17Z
dc.date.available2020-06-25T15:13:17Z
dc.date.issued2003
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: The aim of this study was to determine the effect of treatment on endotelin-1 concentration that is considered to have role in etiopathogenesis of eclampsia and preeclampsia. Methods: Nine patients with eclampsia and 12 patients with preeclampsia were included to the study. Endothelin-1 levels were measured before and after magnesium sulfate treatment. After the magnesium sulfate administration, if the blood pressure was still elevated, nifedipine was given. Results: Endothelin-1 levels of preeclamptic patients before and after magnesium sulfate treatment were 16.9±2.3 fmol/ml and 14.6±1.9 fmol/ml respectively (P<0.05). The same measurements of eclamptic patients were 18.1±3.2 and 14.7±3.4 respectively (P<0.05). The mean blood pressures of preeclamptic patients before and after magnesium sulfate were 125.8±7.3 mm-Hg, 118.2±8. 7 mm-Hg respectively, and the same measurements of eclamptic patients were 136.0±12.4 mm-Hg and 123.1±10.6 mm-Hg respectively (P<0.05, P<0.05). Conclusion: Treatment had been found to have negative effects on endothelin-1 levels that is considered to play an important role on etiopathogenesis of eclampsia and preeclampsia.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1081/PRG-120021064
dc.identifier.endpage191en_US
dc.identifier.issn10641955
dc.identifier.issue2en_US
dc.identifier.pmid12909003
dc.identifier.scopus2-s2.0-18244427462
dc.identifier.scopusqualityQ2
dc.identifier.startpage185en_US
dc.identifier.urihttps://doi.org/10.1081/PRG-120021064
dc.identifier.urihttps://hdl.handle.net/20.500.12587/1709
dc.identifier.volume22en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofHypertension in Pregnancy
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEclampsiaen_US
dc.subjectEndothelin-1en_US
dc.subjectMagnesium sulfateen_US
dc.subjectMean arterial pressureen_US
dc.subjectPreeclampsiaen_US
dc.titleThe Effect of Treatment on Endothelin-1 Concentration and Mean Arterial Pressure in Preeclampsia and Eclampsiaen_US
dc.typeArticle

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