A detailed study on multifaceted bioactivities of the extracts and isolated compounds from truffle Reddellomyces parvulosporus

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dc.authoridTel-Çayan, Gülşen/0000-0002-1916-7391
dc.authoridDuru, Mehmet Emin/0000-0001-7252-4880
dc.contributor.authorÇayan, Fatih
dc.contributor.authorTel-Çayan, Gülşen
dc.contributor.authorDeveci, Ebru
dc.contributor.authorDuru, Mehmet Emin
dc.contributor.authorTürk, Mustafa
dc.date.accessioned2025-01-21T16:34:58Z
dc.date.available2025-01-21T16:34:58Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractMushrooms and truffles are attracting attention as a new generation of biotherapeutics. In the current study, isolation, phenolic and organic acid composition, and antioxidant, cytotoxic, anticholinesterase activities of truffle Reddellomyces parvulosporus were examined. Four known compounds (brassicasterol (1), ergosterol peroxide (2), fumaric acid (3) and mannitol (4)) were isolated with the combination of chromatographic techniques. Fumaric acid (54.74 +/- 0.85 mu g g(-1)) was found as the major compound by HPLC-DAD. All isolated compounds were bioassayed for antioxidant, cytotoxic, anticholinesterase, anti-tyrosinase, anti-urease, anti-alpha-glucosidase and anti-alpha-amylase activities. Compound 1 indicated notable cytotoxic activity on MCF-7 (IC50: 38.08 +/- 0.75 mu g mL(-1)) and compound 3 on H1299 (IC50: 62.37 +/- 0.75 mu g mL(-1)). Also, compounds 1 (84.55 +/- 1.14%) and 2 (84.90 +/- 0.10%) showed higher anti-urease activity than thiourea (78.57 +/- 0.22%), while compound 2 (66.31 +/- 0.08%) displayed near-standard anti-BChE activity. Also, being the first to emphasise the potential of R. parvulosporus as a natural food additive, this study evidenced its medicinal importance by revealing bioactive compounds and properties.
dc.description.sponsorshipScientific and Technological Research Council of Turkey [TUBITAK-114Z644]
dc.description.sponsorshipThis study is a part of F.C.'s PhD thesis. The authors would like to thank to The Scientific and Technological Research Council of Turkey (Project number: TUBITAK-114Z644) for the financial support.
dc.identifier.doi10.1111/ijfs.15190
dc.identifier.endpage1419
dc.identifier.issn0950-5423
dc.identifier.issn1365-2621
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85107921165
dc.identifier.scopusqualityQ1
dc.identifier.startpage1411
dc.identifier.urihttps://doi.org/10.1111/ijfs.15190
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24048
dc.identifier.volume57
dc.identifier.wosWOS:000661906500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofInternational Journal of Food Science and Technology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectAntioxidant activity; cytotoxic activity; enzyme inhibitory activity; isolation; mushroom; R; parvulosporus; truffle
dc.titleA detailed study on multifaceted bioactivities of the extracts and isolated compounds from truffle Reddellomyces parvulosporus
dc.typeArticle

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