Effects of cerium oxide on liver tissue in liver ischemia-reperfusion injury in rats undergoing sevoflurane anesthesia

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dc.authoridKucuk, Aysegul/0000-0001-9316-9574
dc.authoridOzdemir, Cagri/0000-0002-1266-8054
dc.contributor.authorGobut, Huseyin
dc.contributor.authorErel, Selin
dc.contributor.authorOzdemir, Cagri
dc.contributor.authorMortas, Tulay
dc.contributor.authorArslan, Mustafa
dc.contributor.authorKucuk, Aysegul
dc.contributor.authorKasapbasi, Esat
dc.date.accessioned2025-01-21T16:38:15Z
dc.date.available2025-01-21T16:38:15Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractDuring liver surgery and transplantation, periods of partial or total vascular occlusion are inevitable and result in ischemia-reperfusion (IR) injury. Nanomedicine uses the latest technological advancement, which has emerged from interdisciplinary efforts involving biomedical sciences, physics and engineering to protect and improve human health. Antioxidant nanoparticles are potential therapeutic agents. The present study investigated the effects of cerium oxide (Co) administration and sevoflurane anesthesia on liver tissue with IR injury. A total of 36 rats were randomly divided into control, Co, IR, IR-Sevoflurane (IRS), Co + IR and Co + IRS groups. In the IR, IRS and Co + IRS groups, hepatic IR was induced. Intraperitoneal Co was administered to the Co groups 30 min before ischemia. Sevoflurane was administered to the IRS and Co + IRS groups during IR injury. Liver tissue samples were examined under the light microscope by staining with hematoxylin and eosin. Thiobarbituric acid (TBARS) levels as well as catalase (CAT) and glutathione-S-transferase (GST) enzyme activity were evaluated in liver tissue samples. The IR group had considerably more hydropic degeneration, sinusoidal dilatation and parenchymal neutrophil infiltration than the Co, IRS, Co + IR and Co + IRS groups. CAT and GST enzyme activity were significantly higher in Co and Co + IR groups compared with the IR group. TBARS levels were significantly lower in Co, IRS, Co + IR and Co + IRS groups compared whit those in the IR group. Intraperitoneal injection of Co with sevoflurane decreased oxidative stress and damage to the liver.
dc.identifier.doi10.3892/etm.2023.11863
dc.identifier.issn1792-0981
dc.identifier.issn1792-1015
dc.identifier.issue4
dc.identifier.pmid36936704
dc.identifier.urihttps://doi.org/10.3892/etm.2023.11863
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24609
dc.identifier.volume25
dc.identifier.wosWOS:000949133600001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpandidos Publ Ltd
dc.relation.ispartofExperimental and Therapeutic Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectcerium oxide; sevoflurane; ischemia-reperfusion; liver; biochemical analysis; histopathological analysis
dc.titleEffects of cerium oxide on liver tissue in liver ischemia-reperfusion injury in rats undergoing sevoflurane anesthesia
dc.typeArticle

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