Serum leptin levels in patients with polycystic ovary syndrome

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dc.contributor.authorTelli, Muhittin H.
dc.contributor.authorYıldırım, Mulazim
dc.contributor.authorNoyan, Volkan
dc.date.accessioned2020-06-25T15:13:16Z
dc.date.available2020-06-25T15:13:16Z
dc.date.issued2002
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: To determine whether polycystic ovary syndrome (PCOS) is related to leptin dysregulation. Design: Prospective study. Setting: Department of Obstetrics and Gynecology in a university hospital. Patient(s): Fifty patients with PCOS (33 nonobese and 17 obese) and 32 control women (19 nonobese and 13 obese) were included in the study. Intervention(s): Serum leptin levels were measured in patients with PCOS and the controls. Correlations between leptin levels and serum hormone levels (FSH, LH, free testosterone, androstenedione, DHEA-S and fasting insulin) were studied. Main Outcome Measure(s): Serum leptin levels and correlations between leptin levels and the hormonal parameters. Result(s): Mean serum leptin levels were not significantly higher in patients with PCOS compared to the control group. Leptin levels were found to be significantly higher in the obese subgroups both in patients with PCOS and in the control women. Leptin levels were found to be higher in obese patients with PCOS compared to obese controls; however, when the levels were evaluated again with covariance analysis excluding body mass index, there was no statistically significant difference. Leptin levels had a positive correlation with body mass index, both in patients with PCOS and the controls. Conclusion(s): Leptin levels were not higher in patients with PCOS compared to the control group; the leptin level was correlated with the amount of fat tissue not only in patients with PCOS but also in healthy women. © 2002 by American Society for Reproductive Medicine.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/S0015-0282(02)02995-3
dc.identifier.endpage935en_US
dc.identifier.issn00150282
dc.identifier.issue5en_US
dc.identifier.pmid12009346
dc.identifier.scopus2-s2.0-0036253285
dc.identifier.scopusqualityQ1
dc.identifier.startpage932en_US
dc.identifier.urihttps://doi.org/10.1016/S0015-0282(02)02995-3
dc.identifier.urihttps://hdl.handle.net/20.500.12587/1694
dc.identifier.volume77en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofFertility and Sterility
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLeptinen_US
dc.subjectPolycystic ovary syndromeen_US
dc.titleSerum leptin levels in patients with polycystic ovary syndromeen_US
dc.typeArticle

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