NLRP3 Expression in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis

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dc.contributor.authorSarialtin, Sezen Yilmaz
dc.contributor.authorKüçükşahin, Orhan
dc.contributor.authorNural, Cemil
dc.contributor.authorKozaci, Leyla Didem
dc.contributor.authorKaygin, Pinar
dc.contributor.authorŞimşek, Gülçin Güler
dc.contributor.authorO?uztüzün, Serpil
dc.date.accessioned2025-01-21T16:28:05Z
dc.date.available2025-01-21T16:28:05Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractRheumatoid arthritis (RA) is a systemic autoimmune disease characterized by painful, swollen, and inflamed joints. Individual, genetic, and environmental factors influence the development of the disease, which causes involvement not only in the joints but also in other extra-articular tissues. However, the etiopathogenesis of the disease has not yet been fully elucidated. NLRP3, a crucial component of the innate immune system, may contribute to recurrent and chronic inflammation, resulting in inflammation-related diseases. Therefore, we aimed to examine the expression pattern of NLRP3 in peripheral blood mononuclear cells isolated from patients with RA using immunocytochemical approaches in this study. Our findings demonstrated that NLRP3 expression was significantly increased in patients with RA compared to the healthy controls (p<0.01). The highest expression among the patient groups was observed in the active period cases, and this expression considerably increased compared to the control group (p<0.01). Patients in the remission period possessed the lowest expression among the patient groups. Since female gender is considered an independent risk factor for the disease, the effect of gender on expressions was also investigated. NLRP3 was expressed at higher levels in female patients than in males; however, this difference was not significant (p>0.05). The expression patterns of the patient and control groups suggest that NLRP3 may be involved in the development and progression of the disease. To our knowledge, our study is the first research investigating NLRP3 expression profile in peripheral blood mononuclear cells obtained from patients with RA using immunocytochemical approaches. The results of our study highlight significant aspects. However, further research using more sensitive methods with a larger number of cases is required to assess the function of NLRP3 in RA and to provide a deeper insight into the mechanism. © 2023 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.
dc.description.sponsorshipAnkara University Scientific Research Projects, (17L0237005)
dc.identifier.doi10.55262/fabadeczacilik.1346586
dc.identifier.endpage492
dc.identifier.issn1300-4182
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85207462486
dc.identifier.scopusqualityQ4
dc.identifier.startpage481
dc.identifier.trdizinid1209746
dc.identifier.urihttps://doi.org/10.55262/fabadeczacilik.1346586
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1209746
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23481
dc.identifier.volume48
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherSociety of Pharmaceutical Sciences of Ankara (FABAD)
dc.relation.ispartofFabad Journal of Pharmaceutical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectInflammasome; inflammation; NLRP3; rheumatoid arthritis
dc.titleNLRP3 Expression in Peripheral Blood Mononuclear Cells of Patients with Rheumatoid Arthritis
dc.typeArticle

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