Effects of Pinealectomy and Melatonin Application on Serum Melatonin, Nesfatin-1 and Ghrelin Levels

Basit Öğe Kaydı
dc.authoridMenevşe, Esma/0000-0002-5477-5667
dc.authoridBaltacı, Saltuk Buğra/0000-0002-9752-7508
dc.contributor.authorSönmez, Saadet
dc.contributor.authorMenevşe, Esma
dc.contributor.authorBaltacı, Saltuk Buğra
dc.contributor.authorÜnal, Ömer
dc.contributor.authorMoğulkoç, Rasim
dc.contributor.authorBaltaci, Abdulkerim Kasım
dc.date.accessioned2025-01-21T16:33:43Z
dc.date.available2025-01-21T16:33:43Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: In this study, it was aimed to investigate the relationship between the pineal gland and ghrelin and nesfatin-1 hormones in rats. Methods: A total of 36 male rats were used in the study, and the animals were divided into 4 groups. Group 1, Control; Group 2, Pinealectomy (Px); Group 3, Px+Melatonin; Group 4 Melatonin. After the end of the experimental applications, melatonin, ghrelin and nesfatin-1 levels (ELISA) were determined in the blood samples taken from the animals. Results: While pinealectomy resulted in suppression of melatonin levels, melatonin supplementation led to a significant increase in blood melatonin levels (p<0.01). Melatonin supplementation suppressed ghrelin levels, while pinealectomy increased ghrelin levels (P<0.01). On the other hand, Nesfatin-1 levels, which increased with melatonin support, were significantly suppressed by pinealectomy (p<0.01). Conclusion: The findings of the study draw attention to an important relationship between the endocrine activity of the pineal gland and the hormones ghrelin and nesfatin-1, which play a critical role in nutrition. Consequently, administration of melatonin inhibits ghrelin but increases nesfatin-1.
dc.description.sponsorshipScientific Research Projects Coordinatorship of Selcuk University [15202028]
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Coordinatorship of Selcuk University (SUBAPK; project no. 15202028).
dc.identifier.doi10.58600/eurjther1747
dc.identifier.endpage533
dc.identifier.issn2564-7784
dc.identifier.issn2564-7040
dc.identifier.issue3
dc.identifier.startpage526
dc.identifier.trdizinid1199980
dc.identifier.urihttps://doi.org/10.58600/eurjther1747
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay1199980
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23845
dc.identifier.volume29
dc.identifier.wosWOS:001158410800035
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherPera Yayincilik Hizmetleri
dc.relation.ispartofEuropean Journal of Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectPinealectomy; melatonin; nutrition; nesfatin-1; ghrelin; rat
dc.titleEffects of Pinealectomy and Melatonin Application on Serum Melatonin, Nesfatin-1 and Ghrelin Levels
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
Tam Metin/Full Text
Boyut:
567.42 KB
Biçim:
Adobe Portable Document Format
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu