DNA-METAL INTERACTION AND THE BIOLOGICAL ACTIVITIES OF METAL COMPLEXES: AN OVERVIEW IN THE LIGHT OF RECENT LITERATURE

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dc.contributor.authorSenol, Ali
dc.contributor.authorAkanbong, Elisha Apatewen
dc.contributor.authorSudagidan, Mert
dc.contributor.authorDevrim, Alparslan Kadir
dc.date.accessioned2025-01-21T16:37:46Z
dc.date.available2025-01-21T16:37:46Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractDeoxyribonucleic acid (DNA), which leads the biological synthesis of proteins and enzymes in living cells and carries genetic information, is a potential target for binding many molecules such as metals, metal complexes, anticancer drugs, and some harmful chemicals. Molecules that bind to DNA by covalent or non-covalent intercalation, electrostatic interaction, and groove binding cause disruption in the double-stranded DNA structure. This situation is of great importance in studies conducted in the field of pharmacy to increase the effectiveness of antitumor and antiviral drugs, in DNA-based disease diagnosis and determination of toxicity properties of metal complexes. The purpose of this review is to evaluate the interactions of DNA-metal complexes and provide information about their determined biological activities.
dc.identifier.doi10.33224/rrch.2021.66.8-9.02
dc.identifier.endpage711
dc.identifier.issn0035-3930
dc.identifier.issue8-9
dc.identifier.scopus2-s2.0-85136829499
dc.identifier.scopusqualityQ4
dc.identifier.startpage701
dc.identifier.urihttps://doi.org/10.33224/rrch.2021.66.8-9.02
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24528
dc.identifier.volume66
dc.identifier.wosWOS:000835326300002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherEditura Acad Romane
dc.relation.ispartofRevue Roumaine De Chimie
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectDNA; metal complexes; DNA-metal interaction; potential drug effect
dc.titleDNA-METAL INTERACTION AND THE BIOLOGICAL ACTIVITIES OF METAL COMPLEXES: AN OVERVIEW IN THE LIGHT OF RECENT LITERATURE
dc.typeReview Article

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