The Effect of Hydrogen-Rich Saline Solution on Erythrocyte Deformability in Lower Limb Ischemia Reperfusion Injury in Rats

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dc.authoridArslan, Mustafa/0000-0003-4882-5063
dc.authoridKucuk, Aysegul/0000-0001-9316-9574
dc.contributor.authorOzer, Abdullah
dc.contributor.authorArslan, Mustafa
dc.contributor.authorComu, Faruk Metin
dc.contributor.authorKucuk, Aysegul
dc.contributor.authorMardin, Baris
dc.contributor.authorKocak, Basak
dc.contributor.authorOktar, Gursel Levent
dc.date.accessioned2025-01-21T16:45:09Z
dc.date.available2025-01-21T16:45:09Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim: We aimed to investigate the effects of HRSS on erythrocyte deformability in lower limb ischemia reperfusion (IR) injury in rats. Methods: Eighteen male Wistar albino rats used in this study. The animals were randomly divided into three experimental groups as control, IR and IR-HRSS. 20 mg.kg-1HRSS was administered (20 mg.kg(-1) i.p)30 min before the procedure. An atraumatic microvascular clamp was placed across the infrarenal abdominal aorta in the IR groups. 120 min ischemia and 120 min reperfusion is applied to the groups. Erythrocytes were obtained from heparinized whole blood samples for deformability measurements. Kruskal-Wallis test was used for independent samples and Mann-Whitney U test was used to analyze differences between groups. Results: Ischemia reperfusion was found to increase relative resistance to the control group. The erythrocyte deformability index was significantly higher in IR and IR-HRSS groups than the control group. HRSS application significantly decreased erythrocyte deformability index compared to IR group. Conclusion: IR induced rats decreased erythrocyte deformability was partially corrected by HRSS. We believe that the protective effects of HRSS in IR injury and its use indications can be demonstrated in detail as long as the findings we have reached in our study are supported by other studies.
dc.identifier.doi10.12996/gmj.2021.62
dc.identifier.endpage272
dc.identifier.issn2147-2092
dc.identifier.issue2A
dc.identifier.scopus2-s2.0-85107395435
dc.identifier.scopusqualityQ4
dc.identifier.startpage270
dc.identifier.urihttps://doi.org/10.12996/gmj.2021.62
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25596
dc.identifier.volume32
dc.identifier.wosWOS:000655003200002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherGazi Univ, Fac Med
dc.relation.ispartofGazi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectHydrogen-rich saline solution; erythrocyte deformability; ischemia reperfusion
dc.titleThe Effect of Hydrogen-Rich Saline Solution on Erythrocyte Deformability in Lower Limb Ischemia Reperfusion Injury in Rats
dc.title.alternativeSiçanlarda, hidrojenle zenginleştirilmiş salin solüsyonunun alt ekstremite iskemi reperfüzyon hasarinda eritrosit deformabilitesine olan etkisi
dc.typeArticle

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