Effects of Meloxicam on oxidative deterioration due to exercise in horses

Basit Öğe Kaydı
dc.contributor.authorGunes, V.
dc.contributor.authorCinar, M.
dc.contributor.authorOnmaz, A. C.
dc.contributor.authorAtalan, G.
dc.contributor.authorYavuz, U.
dc.date.accessioned2020-06-25T17:51:51Z
dc.date.available2020-06-25T17:51:51Z
dc.date.issued2011
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn this study, the effects of meloxicam, a not steroidal anti-inflammatory drug (NSAID), on the oxidative status were evaluated in exercised horses. Sixteen healthy horses were normally trained for 2 hours and immediately after, the half of them were intravenously injected by a single dose of meloxicam (0.6 mg/kg) whereas the 8 others were treated with NaCl 0.9% in the same way. Physical parameters (rectal temperature, heart and respiratory frequencies) and eventual inflammatory clinical signs, venous blood gas, serum biochemical markers such as glucose and protein concentrations, aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) activities and plasma malondialdehyde (MDA) concentrations and superoxide dismutase (SOD) activities were investigated before (-2 hours), immediately after the exercise and 1, 3, 5 and 7 hours after. Immediately after the exercise which has induced a transient CO2 accumulation coupled to a high and prolonged O-2 consumption, the physical parameters, the serum AST activities and the plasma MDA concentrations significantly increased whereas the plasma SOD activities were greatly reduced. Compared to the control horses, the meloxicam treated horses exhibited a more rapid clinical recovery associated to a more efficient CO2 elimination and tissue O-2 delivery, less prolonged AST variations and marked increases in the SOD activities in the post-exercise period. These results demonstrate that a strenuous exercise induced an oxidative stress in horses and that meloxicam affects the oxidative status by strengthening the SOD activity.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage264en_US
dc.identifier.issn0035-1555
dc.identifier.issn2258-0646
dc.identifier.issue5en_US
dc.identifier.startpage258en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5009
dc.identifier.volume162en_US
dc.identifier.wosWOS:000292780100007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherEcole Nationale Veterinaire Toulouseen_US
dc.relation.ispartofRevue De Medecine Veterinaire
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHorseen_US
dc.subjectexerciseen_US
dc.subjectmeloxicamen_US
dc.subjectoxidative stressen_US
dc.subjectsuperoxide dismutaseen_US
dc.titleEffects of Meloxicam on oxidative deterioration due to exercise in horsesen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
Ä°sim:
Effects of Meloxicam on oxidative deterioration due to exercise in horses.pdf
Boyut:
141.32 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
Ä°ndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu