MTHFR C677T (rs1801133) genetic polymorphism is associated with development risk of essential hypertension in the Turkish population

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dc.authoridekim, meral/0000-0002-7146-5935
dc.authoridEkim, Hasan/0000-0002-7245-3872
dc.authoridMUDERRISOGLU, AHMET/0000-0003-2954-360X
dc.authoridER, Zafer Cengiz/0000-0001-7129-1157
dc.contributor.authorEr, Zafer Cengiz
dc.contributor.authorMuderrisoglu, Ahmet
dc.contributor.authorEkim, Meral
dc.contributor.authorEkim, Hasan
dc.date.accessioned2025-01-21T16:42:46Z
dc.date.available2025-01-21T16:42:46Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground Hypertension is a serious condition that is spread worldwide and may lead to severe complications such as heart attack, stroke, hypertensive retinopathy, and renal failure. Although some genetic and environmental risk factors are known to play a role in the etiology of hypertension, like most of the other multi-factorial diseases, its etiology is yet to be fully elucidated. Our study aimed to investigate the effects of methylenetetrahydrofolate reductase (MTHFR) C677T (rs1801133) and A1298C (rs1801131), factor V Leiden (FVL) G1691A (rs6025), and prothrombin (PT) G20210A (rs1799963) genetic polymorphisms on the development risk of essential hypertension and level of blood pressure in hypertensive patients. Results The frequency of the homozygous polymorphic TT genotype for the MTHFR C677T polymorphism was significantly higher in male hypertensive patients than in the male control group (27% vs 6.3%, p = 0.028). The rate of the variant T allele for the MTHFR C677T polymorphism was also significantly higher in male hypertensive patients compared to male healthy controls (51.4% vs 21.9%, p = 0.0004). There was no difference among hypertensive patients and healthy controls regarding the frequencies of MTHFR A1298C, FVL G1691A and PT G20210A polymorphisms. In addition, we found no difference between genotype groups regarding systolic and diastolic blood pressure levels in hypertensive patients. Conclusions Homozygous polymorphic TT genotype and variant T allele for the MTHFR C677T polymorphism may be considered as a risk factor for the development of essential hypertension in the Turkish male population.
dc.identifier.doi10.1186/s43042-022-00221-z
dc.identifier.issn1110-8630
dc.identifier.issn2090-2441
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85122977341
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.1186/s43042-022-00221-z
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25129
dc.identifier.volume23
dc.identifier.wosWOS:000743534800001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringernature
dc.relation.ispartofEgyptian Journal of Medical Human Genetics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectMTHFR; FVL; PT; Essential hypertension; Polymorphism
dc.titleMTHFR C677T (rs1801133) genetic polymorphism is associated with development risk of essential hypertension in the Turkish population
dc.typeArticle

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