Modification of halloysite clay nanotubes with various alkyl halides, and their characterization, blood compatibility, biocompatibility, and genotoxicity

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dc.contributor.authorCan M.
dc.contributor.authorDemirci S.
dc.contributor.authorYildrim Y.
dc.contributor.authorÇoban C.Ç.
dc.contributor.authorTurk M.
dc.contributor.authorSahiner N.
dc.date.accessioned2021-01-14T18:11:13Z
dc.date.available2021-01-14T18:11:13Z
dc.date.issued2021
dc.departmentKKÜ
dc.description.abstractHalloysite nanotubes (HNTs) clay were modified with alkyl halides, bromoethane (BrE), bromodecane (BrD), and bromooctadecane (BrOD), respectively. The FT-IR spectra of modified HNTs demonstrated an increase in the intensity of aliphatic –CH2 peaks at 2920 and 2850 cm?1 proportional to the number of C atoms in the modifying agent confirming the success of chemical modification with corresponding alkyl halides. Surface charge of NaOH treated HNTs, ?65.7 ± 5.1 mV was increased to ?37.1 ± 2.4, ?40.6 ± 5.3, and ?44.7 ± 1.9 mV, respectively upon chemical modification with BrE, BrD, and BrOD. The Surface area of the HNT clays, 43.2 ± 1.3 m2/g was also increased to 59.8 ± 2.7, 56.9 ± 2.1, and 47.9 ± 1.7 m2/g for BrE, BrD, and BrOD modified HNT clays, respectively. Base-activated HNT clays at 1 mg/mL concentration found to be nonhemolytic with 3.5 ± 1.2% hemolysis ratio, whereas HNT-BrOD clays were slightly exceeded hemolytic safety level with 6.6 ± 0.2% hemolysis induction. Base-activated HNT and HNT-BrOD clays were found to show antithrombogenic character with more than 100% blood clotting indexes,107.6 ± 1.8, and 106.5 ± 1.9%, respectively. Cytotoxicity studies of HNTs on L929 fibroblast cells revealed that HNTs in 12.5–200 ?g/mL concentration range were shown dose-dependent cell viability, and above 50% cell viability was maintained at 200 ?g/mL in all forms of HNT based clays administered. © 2020 Elsevier B.V.en_US
dc.identifier.doi10.1016/j.matchemphys.2020.124013
dc.identifier.issn0254-0584
dc.identifier.scopus2-s2.0-85096686054
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.matchemphys.2020.124013
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12919
dc.identifier.volume259en_US
dc.identifier.wosWOS:000615729200005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Ltden_US
dc.relation.ispartofMaterials Chemistry and Physics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiocompatible HNTen_US
dc.subjectBlood compatible HNTen_US
dc.subjectGenotoxicityen_US
dc.subjectNatural halloysite nanoclayen_US
dc.subjectSurface modified HNTen_US
dc.titleModification of halloysite clay nanotubes with various alkyl halides, and their characterization, blood compatibility, biocompatibility, and genotoxicityen_US
dc.typeArticle

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