Modification of halloysite clay nanotubes with various alkyl halides, and their characterization, blood compatibility, biocompatibility, and genotoxicity

Basit Öğe Kaydı
dc.contributor.authorCan, Mehmet
dc.contributor.authorDemirci, Şahin
dc.contributor.authorYıldırım, Yıldız
dc.contributor.authorÇoban, Canan Çakır
dc.contributor.authorTürk, Mustafa
dc.contributor.authorŞahiner, Nurettin
dc.date.accessioned2021-01-14T18:11:13Z
dc.date.available2021-01-14T18:11:13Z
dc.date.issued2021
dc.departmentKKÜ
dc.description.abstractHalloysite nanotubes (HNTs) clay were modified with alkyl halides, bromoethane (BrE), bromodecane (BrD), and bromooctadecane (BrOD), respectively. The FT-IR spectra of modified HNTs demonstrated an increase in the intensity of aliphatic –CH2 peaks at 2920 and 2850 cm?1 proportional to the number of C atoms in the modifying agent confirming the success of chemical modification with corresponding alkyl halides. Surface charge of NaOH treated HNTs, ?65.7 ± 5.1 mV was increased to ?37.1 ± 2.4, ?40.6 ± 5.3, and ?44.7 ± 1.9 mV, respectively upon chemical modification with BrE, BrD, and BrOD. The Surface area of the HNT clays, 43.2 ± 1.3 m2/g was also increased to 59.8 ± 2.7, 56.9 ± 2.1, and 47.9 ± 1.7 m2/g for BrE, BrD, and BrOD modified HNT clays, respectively. Base-activated HNT clays at 1 mg/mL concentration found to be nonhemolytic with 3.5 ± 1.2% hemolysis ratio, whereas HNT-BrOD clays were slightly exceeded hemolytic safety level with 6.6 ± 0.2% hemolysis induction. Base-activated HNT and HNT-BrOD clays were found to show antithrombogenic character with more than 100% blood clotting indexes,107.6 ± 1.8, and 106.5 ± 1.9%, respectively. Cytotoxicity studies of HNTs on L929 fibroblast cells revealed that HNTs in 12.5–200 ?g/mL concentration range were shown dose-dependent cell viability, and above 50% cell viability was maintained at 200 ?g/mL in all forms of HNT based clays administered. © 2020 Elsevier B.V.en_US
dc.identifier.doi10.1016/j.matchemphys.2020.124013
dc.identifier.issn0254-0584
dc.identifier.scopus2-s2.0-85096686054
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.matchemphys.2020.124013
dc.identifier.urihttps://hdl.handle.net/20.500.12587/12919
dc.identifier.volume259en_US
dc.identifier.wosWOS:000615729200005
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Ltden_US
dc.relation.ispartofMaterials Chemistry and Physics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBiocompatible HNTen_US
dc.subjectBlood compatible HNTen_US
dc.subjectGenotoxicityen_US
dc.subjectNatural halloysite nanoclayen_US
dc.subjectSurface modified HNTen_US
dc.titleModification of halloysite clay nanotubes with various alkyl halides, and their characterization, blood compatibility, biocompatibility, and genotoxicityen_US
dc.typeArticle

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