The effects of fullerenol nanoparticles on erythrocyte deformability in sevoflurane applied rats

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dc.authoridKucuk, Aysegul/0000-0001-9316-9574
dc.authoridArslan, Mustafa/0000-0003-4882-5063
dc.contributor.authorSivgin, Volkan
dc.contributor.authorKucuk, Aysegul
dc.contributor.authorComu, Faruk Metin
dc.contributor.authorYalcin, Ayse Gulfem
dc.contributor.authorArslan, Mustafa
dc.date.accessioned2025-01-21T16:45:24Z
dc.date.available2025-01-21T16:45:24Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground & objective: Oxidative damage causing alterations in erythrocyte deformability due to anesthesia might be one of the factors responsible for the deterioration of the tissue and organ perfusion. The antioxidant properties of fullerenol nanoparticles, used in medical field together with the developing technology, have been shown in the literature. We investigated the effects of fullerenol nanoparticles, used before sevoflurane anesthesia, on the erythrocyte deformability in the rats. Methodology: Twenty-four male Wistar Albino rats were used in this study and randomly divided into four groups, six in each group; Group C (Control Group), Group S (Group Sevoflurane), Group F (Group Fullerenol), Group FS (Group Fullerenol-Sevoflurane). Fullerenol was given to the Group F and Group FS at a dose of 100 mg/kg. Sevoflurane was administered to rats in the Groups S and FS at 3% concentration. Erytrocytes deformability was measured by the constant-current filtrometre system and the deformability index was interpreted. All the data were processed by variance analysis in SPSS 22.0 for Windows statistical software. Variance analysis and Kruskal-Wallis test were used to evaluate the data. Mann-Whitney U test with Bonferroni correction were used to evaluate the variables with significance. Results: Relative resistance increased in all groups due to sevoflurane administration (p < 0.0001). The erythrocyte deformability index was significantly higher in the sevoflurane group than in the control and fullerenol groups (p < 0.0001, p = 0.002, respectively). Fullerenol administration, before 30 min of sevoflurane treatment, was found to decrease erythrocyte deformability index significantly compared to sevoflurane group (p = 0.017). Conclusion: Administring 100 mg/kg fullerenol nanoparticles intraperitoneally 30 min before sevoflurane reduces erythrocyte deformability.
dc.identifier.doi10.35975/apic.v25i5.1619
dc.identifier.endpage606
dc.identifier.issn1607-8322
dc.identifier.issn2220-5799
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85123383427
dc.identifier.scopusqualityQ4
dc.identifier.startpage602
dc.identifier.urihttps://doi.org/10.35975/apic.v25i5.1619
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25639
dc.identifier.volume25
dc.identifier.wosWOS:000706791400009
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherAnaesthesia Pain & Intensive Care
dc.relation.ispartofAnaesthesia Pain & Intensive Care
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectAnimals; Rats; Sevoflurane; Fullerenol; Fullerenes*; pharmacology; Nanoparticles; Oxidative Stress; Erythrocyte deformability
dc.titleThe effects of fullerenol nanoparticles on erythrocyte deformability in sevoflurane applied rats
dc.typeArticle

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