The Effects of Esmolol on Erythrocyte Deformability in Rat Liver Ischemia-Reperfusion Injury

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dc.authoridKucuk, Aysegul/0000-0001-9316-9574
dc.authoridSalman, Nevriye/0000-0001-9416-4177
dc.authoridArslan, Mustafa/0000-0003-4882-5063
dc.contributor.authorSabuncu, Ulku
dc.contributor.authorKucuk, Aysegul
dc.contributor.authorComu, Faruk Metin
dc.contributor.authorSalman, Nevriye
dc.contributor.authorKip, Gulay
dc.contributor.authorUnal, Yusuf
dc.contributor.authorArslan, Mustafa
dc.date.accessioned2025-01-21T16:45:24Z
dc.date.available2025-01-21T16:45:24Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: Esmolol has protective effects in ischemia reperfusion (IR) injury. The purpose of our study was to look into the effects of this which esmolol on erythrocyte deformability in rat liver IR injury model. Materials and Methods: We used 24 Wistar albino rats as subjects in our study. They were divided into 4 groups; randomized control group (group C; n=6), esmolol group 200 mu g/kg/min intravenously (group E; n=6), IR group (group IR; n=6) and IR group with esmolol 200 mu g/kg/min intravenously (group IR-E; n=6). Erythrocyte packs were prepared from heparinized blood samples and deformability measurements were performed. Results: It was discovered that ischemia reperfusion increased the relative resistance when compared to control group (p<0.0001). Erythrocyte deformibility index was found to be higher in IR and IR-E groups compared to control group (p<0.0001, p=0.002, respectively). Esmolol application decreased the erythrocyte deformibiltiy index when compared to control group (p=0.017). Conclusion: In this research, esmolol application has improved the ertyhrocyte deformibity in liver rat IR injury partially. We also found that esmolol had beneficial effects by reversing undesirable effects of IR. Further studies with larger volume are required to support our promising results.
dc.identifier.doi10.12996/gmj.2021.82
dc.identifier.endpage358
dc.identifier.issn2147-2092
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85109464325
dc.identifier.scopusqualityQ4
dc.identifier.startpage355
dc.identifier.urihttps://doi.org/10.12996/gmj.2021.82
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25638
dc.identifier.volume32
dc.identifier.wosWOS:000667265000002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherGazi Univ, Fac Med
dc.relation.ispartofGazi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectIschemia-reperfusion; liver; esmolol; erythrocyte deformability; rat
dc.titleThe Effects of Esmolol on Erythrocyte Deformability in Rat Liver Ischemia-Reperfusion Injury
dc.typeArticle

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