Effects of Amantadine on Liver and Lung Tissue in Hepatic Ischemia Reperfusion Injury in Rats

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dc.authoridIrmak Gozukara, Sezen/0000-0002-4825-4611
dc.authoridArslan, Mustafa/0000-0003-4882-5063
dc.authoridYAZAR, HAYRULLAH/0000-0002-1164-4720
dc.authoridTas Tuna, Ayca/0000-0001-6764-2647
dc.contributor.authorSahin, Fatih
dc.contributor.authorTuna, Ayca Tas
dc.contributor.authorUnal, Yusuf
dc.contributor.authorArslan, Mustafa
dc.contributor.authorYazar, Hayrullah
dc.contributor.authorSezen, Saban Cem
dc.contributor.authorGozukara, Sezen Irmak
dc.date.accessioned2025-01-21T16:38:14Z
dc.date.available2025-01-21T16:38:14Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: N-Methyl D-Aspartate (NMDA) receptor blockers have been shown to have protective effects against ischemia/reperfusion (I/R) injury in various tissues. The aim of this study was to investigate the effects of amantadine on liver and lung tissue in hepatic I/R injury. Materials and Methods: Twenty-four rats divided into 4 groups: the Sham Group (S), the Amantadine Group (A), the I/R Group (I/R) and the I/R + Amantadine Group (I/R-A). In Group A and Group I/R-A, 45 mg/kg of amantadine was administered before surgery. In Group I/R and Group I/R-A, an atraumatic vascular clamp was applied to the structures in the left portal triad for 45 minutes and reperfusion period was 2 hours after declampage. Malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) enzyme levels were were studied in liver and lung tissues. Additionally tissues were examined histopathologically. Results: No significant difference was observed in tissue MDA, SOD, and CAT levels among four groups (p >0.05). Polymorphonuclear cell infiltration and the scores of hepatocyte degeneration, sinusoidal dilatation, pycnotic core, and necrosis cell were significantly higher in Group I/R than other groups (p<0.05). Regarding to the lung tissue, the neutrophil/lymphocyte infiltration score was significantly lower in Group S and A than in Group I/R (respectively; p= 0.007, 0.011), and it was significantly higher in Group I/R-A than in Group S (p = 0.014). The alveolar wall thickening score was significantly higher in Group I/R than the other groups (p <0.0001). Conclusion: Amantadine may have a protective effect against I/R damage, as it reduces histopathological changes caused by I/R damage.
dc.description.sponsorshipSakarya University Scientific Research Projects; [40-02-006]
dc.description.sponsorshipThis work was supported by the Sakarya University Scientific Research Projects (40-02-006, 2017) .
dc.identifier.doi10.12996/gmj.2023.2
dc.identifier.endpage15
dc.identifier.issn2147-2092
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85151033620
dc.identifier.scopusqualityQ4
dc.identifier.startpage10
dc.identifier.urihttps://doi.org/10.12996/gmj.2023.2
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24603
dc.identifier.volume34
dc.identifier.wosWOS:000908834300002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherGazi Univ, Fac Med
dc.relation.ispartofGazi Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectAmantadine; Hepatic Ischemia-Reperfusion; Liver; Lung; Liver Surgery
dc.titleEffects of Amantadine on Liver and Lung Tissue in Hepatic Ischemia Reperfusion Injury in Rats
dc.title.alternativeAmantadinin Ratlarda Hepatik İskemi Reperfüzyon Hasarinda Karaciğer ve Akciğer Dokusu Üzerine Etkileri
dc.typeArticle

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