Synthesis and characterization of poly(N-Vinyl-2-pyrrolidone) grafted sodium alginate hydrogel beads for the controlled release of indomethacin

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dc.contributor.authorIşıklan, Nuran
dc.contributor.authorİnal, Murat
dc.contributor.authorYigitoglu, Mustafa
dc.date.accessioned2020-06-25T17:44:17Z
dc.date.available2020-06-25T17:44:17Z
dc.date.issued2008
dc.departmentKırıkkale Üniversitesi
dc.description.abstractGraft copolymers of sodium alginate (NaAlg) with N-vinyl-2-pyrrolidone were prepared using azobisisobutyronitrile as initiator. The graft copolymers (NaAlg-g-PVP) were characterized with Fourier transform infrared spectroscopy, elemental analysis, and differential scanning calorimetry. Polymeric hydrogel beads of NaAlg and NaAlg-g-PVP were prepared by crosslinking method Using glutaraldehyde (GA) as a crosslinker in the hydrochloric acid catalyst (HCl) and these beads were used to deliver anti-inflammatory drug, indomethacin (IM). Chemical stability of the IM after encapsulation into beads was confirmed by FTIR. Preparation conditions of the NaAlg-g-PVP beads,ere optimized by considering the percentage entrapment efficiency, particle size, swelling capacity and their release data. In vitro release Studies were performed in simulated gastric fluid (pH 1.2) for the initial 2 h, followed by simulated intestinal fluid (pH 7.4) for 4 h. Effects of GA concentration, exposure time to GA, drug/polyrner (d/p) ratio, and concentration of HCl on the release of IM were discussed. It was observed that IM release from the beads decreased with increasing GA concentration and exposure time. IM release also decreases with increasing till) ratio and HCI concentration. The highest IM release was obtained to be 77%, for beads crosslinked with 0.027M GA. Swelling experiments were also performed to compute molecular mass between crosslinks of the beads. (c) 2008 Wiley Periodicals, Inc.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1002/app.28577
dc.identifier.endpage493en_US
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-54749130334
dc.identifier.scopusqualityQ2
dc.identifier.startpage481en_US
dc.identifier.urihttps://doi.org/10.1002/app.28577
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4065
dc.identifier.volume110en_US
dc.identifier.wosWOS:000258633800059
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Applied Polymer Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectgraft copolymeren_US
dc.subjectcontrolled releaseen_US
dc.subjectdrug delivery systemsen_US
dc.subjectindomethacinen_US
dc.subjecthydrophilic polymersen_US
dc.titleSynthesis and characterization of poly(N-Vinyl-2-pyrrolidone) grafted sodium alginate hydrogel beads for the controlled release of indomethacinen_US
dc.typeArticle

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