Spectral analysis and biological activity assessment of silver doped hydroxyapatite

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dc.authoridBozer, Busra/0000-0002-7280-4417
dc.authoridErdem, Umit/0000-0002-0480-8176
dc.contributor.authorErdem, Umit
dc.contributor.authorBozer, Busra Moran
dc.contributor.authorTurkoz, Mustafa B.
dc.contributor.authorMetin, Aysegul U.
dc.contributor.authorYildirim, Gurcan
dc.contributor.authorTurk, Mustafa
dc.contributor.authorNezir, Saffet
dc.date.accessioned2025-01-21T16:44:30Z
dc.date.available2025-01-21T16:44:30Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn this study, the hydroxyapatite biomaterials are produced by the precipitation method and the role of silver doping within the different molar ratios of 2.0, 5.0, and 10.0% are investigated with some fundamental analysis, including powder XRD, SEM, EDS, FTIR, Raman, and material densities. In vitro biocompatibility assessment is conducted with cytotoxicity and agar diffusion tests. Moreover, genotoxicity tests determine whether the biomaterials produced cause the mutations or not. In addition, a hemolytic effect test examines the variation of hemolytic behavior of compounds. Also, the cell migration experiments inspect the influence of silver ion levels in biomaterials on many biological processes. The experimental results reveal that the honeycomb-patterned morphological structures are obtained for all the products. FTIR and Raman analyses reveal that the dramatic changes in the characteristic functional group peaks are obtained with the increment in the amount of silver ions. The experimental parts related to the biocompatibility assessment of the study show that there seems to be deterioration in biocompatibility as the silver ion-doping level increases in the system. To sum up, the ideal doping value for bone tissue engineering applications is found to be 2%.
dc.identifier.doi10.1080/21870764.2021.1989749
dc.identifier.endpage1545
dc.identifier.issn2187-0764
dc.identifier.issue4
dc.identifier.scopus2-s2.0-85117349655
dc.identifier.scopusqualityQ2
dc.identifier.startpage1524
dc.identifier.urihttps://doi.org/10.1080/21870764.2021.1989749
dc.identifier.urihttps://hdl.handle.net/20.500.12587/25475
dc.identifier.volume9
dc.identifier.wosWOS:000708270000001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal of Asian Ceramic Societies
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectHydroxyapatite; silver doping; biocompability; cell migration
dc.titleSpectral analysis and biological activity assessment of silver doped hydroxyapatite
dc.typeArticle

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