Design and fabrication of hybrid triple-responsive ?-carrageenan-based nanospheres for controlled drug delivery

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dc.contributor.authorGeyik, Gülcan
dc.contributor.authorIşıklan, Nuran
dc.date.accessioned2025-01-21T16:27:13Z
dc.date.available2025-01-21T16:27:13Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn the last two decades, the utilization of magnetic nanospheres in intelligent polymeric structures have received increased attention of researchers in numerous biomedical applications. Here, hybrid nanostructured triple-responsive magnetic nanospheres (?-Car-g-P(AA/DMA)@Fe3O4) containing inorganic iron oxide core (Fe3O4) and organic graft copolymeric shell based on ?-carrageenan (?-Car) and poly(acrylic acid/dimethylaminoethyl methacrylate) (P(AA/DMA)) were synthesized by microwave induced co-precipitation technique. The structure, size, surface morphology, magnetic property and stability of synthesized ?-Car-g-P(AA/DMA)@Fe3O4 magnetic nanospheres were characterized using FTIR, UV, XRD, TEM, Zeta-sizer, and VSM. ?-Car-g-P(AA/DMA)@Fe3O4 nanospheres were loaded with 5-Fluorouracil (5-FU) as an antineoplastic drug, and their 5-FU release behavior was explored in diverse graft yields, pH values, temperatures and in the existence of an alternating magnetic field. The ?-Car-g-P(AA/DMA)@Fe3O4 nanospheres demonstrated pH-, thermo-, and magnetic field-responsive 5-FU release with good biocompatibility and excellent anticancer activity. In addition, 5-FU release under 50 mT magnetic field reached to 100% within 4 h. This work exhibits that hybrid nanospheres have a triple stimuli-responsive influence, which is of principal importance for the future design and application of multi-functional responsive platforms to develop externally stimulated release of active agents and their healthcare capability. © 2021 Elsevier B.V.
dc.description.sponsorshipK?r?kkale University; Kırıkkale University, (2018/055)
dc.identifier.doi10.1016/j.ijbiomac.2021.10.007
dc.identifier.endpage715
dc.identifier.issn0141-8130
dc.identifier.pmid34637816
dc.identifier.scopus2-s2.0-85117113370
dc.identifier.scopusqualityQ1
dc.identifier.startpage701
dc.identifier.urihttps://doi.org/10.1016/j.ijbiomac.2021.10.007
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23296
dc.identifier.volume192
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofInternational Journal of Biological Macromolecules
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectMagnetic iron oxide; Poly(acrylic acid); Poly(dimethylaminoethyl methacrylate); Stimuli-responsive nanosystem; ?-carrageenan
dc.titleDesign and fabrication of hybrid triple-responsive ?-carrageenan-based nanospheres for controlled drug delivery
dc.typeArticle

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