Clinical efficacy of two-phase leukocyte filtration in high-risk patients undergoing coronary revascularization with cardiopulmonary bypass

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dc.contributor.authorGunaydin S.
dc.contributor.authorModine T.
dc.contributor.authorSari T.
dc.contributor.authorZorlutuna Y.
dc.contributor.authorGourlay T.
dc.date.accessioned2020-06-25T15:14:20Z
dc.date.available2020-06-25T15:14:20Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe purpose of this study was to investigate the clinical outcome, inflammatory response and myocardial function in high-risk patients undergoing three different leukocyte depletion strategies. Over a four-month period, forty patients (EuroSCORE 6+) undergoing coronary revascularization were prospectively randomized to one of the four perfusion protocols: Group 1 (N = 10): Conventional circuits (ECC) + two leukocyte filters (LG6B, Pall, USA) with the method of two-phase (continuous + strategic) leukofiltration; Group 2 (N = 10): ECC + single leukocyte filter with the method of continuous leukofiltration; Group 3 (N = 10): ECC + single leukocyte filter with the method of strategic leukofiltration; Group 4 (N = 10) Control: ECC without leukocyte filtration. Blood samples were collected at T1: Baseline, T2: On CPB, T3: X-Clamp, T4: Off CPB, T5: ICU24 and T6: ICU48. Perioperative follow-up was thoroughly monitored. Leukocyte counts in double filter and strategic filtration groups demonstrated significant differences at T4 ( p < .05 vs. control). TNF-alpha levels were significantly lower in Group 1 at T4 and procalcitonin levels at T5 and T6 ( p < .05 vs. control). CKMB levels demonstrated well preserved myocardium in double filter group ( p < .05 vs. control). Brain natriuretic peptide levels in double filter group were significantly lower at T5 and T6 with respect to Group 2 ( p < .05) and control ( p < .001). Matrixmetallopeptidase 9 and D-Dimer levels in double filter group were significantly lower at T5 and T6 ( p < .05 vs. control). Two-phase leukofiltration is associated with some compound benefit over continuous deployment in high-risk patients. A larger more powerful study than this pilot one is warranted for further evaluation.en_US
dc.identifier.endpage156en_US
dc.identifier.issn00221058
dc.identifier.issue3en_US
dc.identifier.pmid19806797
dc.identifier.scopus2-s2.0-75149140128
dc.identifier.scopusqualityQ2
dc.identifier.startpage149en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2084
dc.identifier.volume41en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofJournal of Extra-Corporeal Technology
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCardiopulmonary bypassen_US
dc.subjectLeukapheresisen_US
dc.subjectLeukocyte filtrationen_US
dc.subjectReperfusion injuryen_US
dc.titleClinical efficacy of two-phase leukocyte filtration in high-risk patients undergoing coronary revascularization with cardiopulmonary bypassen_US
dc.typeArticle

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