Evaluation of putamen area and cerebral peduncle with surrounding cistern in patients with Parkinson’s disease: is there a difference from controls in cranial MRI?

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dc.contributor.authorSay, Bahar
dc.contributor.authorBayar Muluk, Nuray
dc.contributor.authorİnal, Mikail
dc.contributor.authorGöncüoğlu, Alper
dc.contributor.authorYörübulut, Serap
dc.contributor.authorErgün, Ufuk
dc.date.accessioned2025-01-21T16:27:35Z
dc.date.available2025-01-21T16:27:35Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: Nigrostriatal dopaminergic neuron loss is essential in pathogenesis of Parkinson’s disease (PD). The purpose of this study was to evaluate nigrostriatal structures including the putamen, cerebral peduncle, widths of interpeduncular cistern, and ambient cistern around the midbrain with conventional cranial magnetic resonance images (MRI) in patients with PD. Methods: The MRI of 56 subjects was included, which was selected from the radiological data system for this retrospective study. The 29 patients with idiopathic PD were included and their disease duration, Hoehn&Yahr stage, and Levodopa equivalent dose (LED) were recorded. The 27 controls had a normal neurologic examination and cranial MRI. All subjects in the patient and control groups had right-hand dominance. Putamen and cerebral peduncle areas and widths of interpeduncular and ambient cisterns were measured in T2 sequences of MRI. Further statistical analysis was applied to exclude gender and age effect on areas. Results: The areas of putamen and cerebral peduncles were significantly reduced in patients with PD compared to the control bilaterally (p < 0.001). Enlargement of interpeduncular and ambient cisterns in patients was higher than in controls, and it was significant (p < 0.001). A correlation was not observed between measurement results and clinical characteristics of patients with PD. Only the cerebral peduncle area/ambient cistern width ratio was significantly correlated with disease duration positively (right r = 0.46 p = 0.012, left r = 0.389 p = 0.037). Conclusion: Clinicians should be careful with conventional MRIs of patients with idiopathic PD in practice. It may be different from controls without any neurological disorder, particularly putamen, cerebral peduncles, interpeduncular, and ambient cisterns. © 2023 Informa UK Limited, trading as Taylor & Francis Group.
dc.identifier.doi10.1080/01616412.2023.2281088
dc.identifier.endpage226
dc.identifier.issn0161-6412
dc.identifier.issue3
dc.identifier.pmid37953510
dc.identifier.scopus2-s2.0-85176955760
dc.identifier.scopusqualityQ3
dc.identifier.startpage220
dc.identifier.urihttps://doi.org/10.1080/01616412.2023.2281088
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23366
dc.identifier.volume46
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor and Francis Ltd.
dc.relation.ispartofNeurological Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectbasal ganglia; imaging; movement disorder; MRI; Parkinson’s disease; substantia nigra
dc.titleEvaluation of putamen area and cerebral peduncle with surrounding cistern in patients with Parkinson’s disease: is there a difference from controls in cranial MRI?
dc.typeArticle

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