INVESTIGATION OF THE MUTAGENIC, CYTOTOXIC AND ANTIMICROBIAL EFFECT OF BIKAVERIN MYCOTOXIN

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dc.authoridKULAHCI, M.Burcu/0000-0002-5007-5209
dc.authoridBeyzi, Ebru/0000-0002-5292-9554
dc.contributor.authorBeyzi, Ebru
dc.contributor.authorKulahci, Meryem Burcu
dc.contributor.authorCerci, Nebahat Aytuna
dc.date.accessioned2025-01-21T16:41:53Z
dc.date.available2025-01-21T16:41:53Z
dc.date.issued2024
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBikaverin is a reddish pigment produced by different fungi species (Mycogone jaapii, Verticillium agaricinum, Beauveria bassiana, Paecilomyces fumosoroseus, Polyporus sulphureus), mainly of the Fusarium genus. Due to its pigment feature, bikaverin can be used as a dye in various fields in the industry. However, it is extremely important to study the mutagenic/genotoxic effects, cytotoxic effects and antimicrobial properties of bikaverin for application of industrial areas. In the study, the mutagenic, cytotoxic and antimicrobial effects of bikaverin were investigated. The mutagenic effect of bikaverin was studied with the Ames test. Salmonella typhimurium TA97a, TA98, TA100, TA102 and TA1535 strains were used in the test. Five different doses of bikaverin (0.075, 0.1, 0.2, 0.3 and 0.5 mu g/plate) were tested against strains. It was determined that there was no mutagenic effect of bikaverin. The cytotoxicity of bikaverin was evaluated by MTT test on L929 fibroblast cell line. Bikaverin demonstrated no cytotoxic effect on L929 fibroblast cell line, according to cell viability calculations that showed >73% for all concentrations (1, 0.5, 0.4, 0.3, 0.2, 0.1, 0.075, 0.05, 0.025, 0.01, 0.005 and 0.001 mu g/mL) examined. Bikaverin's IC50 value was determined to be 1.79 +/- 0.51 g/mL. The antimicrobial activity of the bikaverin was evaluated by using the microdilution method. Bikaverin was found to have antimicrobial effects on Methicillin resistant Staphylococcus aureus, Vancomycin resistant Enterococcus faecalis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Candida albicans and Candida krusei, as MIC values ranged from 1.25 -5 mu g/ mL.
dc.description.sponsorshipScientific Research Projects of the Gazi University, Turkey; [FGA-2022-7657]
dc.description.sponsorshipWe thanks the Scientific Research Projects of the Gazi University, Turkey for the scholarship to the authors (Grant number: FGA-2022-7657) .
dc.identifier.doi10.14393/BJ-v40n0a2024-70910
dc.identifier.issn1981-3163
dc.identifier.scopus2-s2.0-85190809726
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.14393/BJ-v40n0a2024-70910
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24974
dc.identifier.volume40
dc.identifier.wosWOS:001199100400021
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherUniv Federal Uberlandia
dc.relation.ispartofBioscience Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectAmes; Antimicrobial Activity; Bikaverin; Cytotoxicity; Mutagenicity; Mycotoxin
dc.titleINVESTIGATION OF THE MUTAGENIC, CYTOTOXIC AND ANTIMICROBIAL EFFECT OF BIKAVERIN MYCOTOXIN
dc.typeArticle

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