Development and characterization of dual sensitive poly(N,N-diethyl acrylamide) grafted alginate microparticles

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dc.contributor.authorIsiklan, Nuran
dc.contributor.authorAltinisik, Zeynep
dc.date.accessioned2020-06-25T18:30:44Z
dc.date.available2020-06-25T18:30:44Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description.abstractTemperature and pH dual sensitive materials have attracted much interest in the fields of tissue engineering and drug delivery. In this study, a novel temperature and pH dual sensitive poly(N,N-diethyl acrylamide) grafted alginate (A-g-PDEA) microparticles were developed for 5-fluorouracil (5-FU) delivery. The structures of 5-FU loaded A-g-PDEA microparticles were characterized by FTIR, DSC, SEM, and XRD analyses. The effect of PDEA grafting percentage, temperature and pH on the swelling ratio and the release of 5-FU was explored. The obtained results displayed that the 5-FU release was controlled by both the temperature and pH of the medium. Furthermore, A-g-PDEA microparticles demonstrated a sustained release of 5-FU compared to free 5-FU. Moreover, the 5-FU release and swelling ratio of A-g-PDEA microparticles decreased with the increase in grafting percentage, crosslinking time and 5-FU/copolymer ratio. All the results indicated that A-g-PDEA microparticles are promising candidates for the sustained and controlled delivery of drugs.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113Z271]en_US
dc.description.sponsorshipThe authors wish to thank the Scientific and Technological Research Council of Turkey (TUBITAK) for their financial support of this study with the grant number of 113Z271.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.colsurfa.2019.05.013
dc.identifier.endpage362en_US
dc.identifier.issn0927-7757
dc.identifier.issn1873-4359
dc.identifier.scopus2-s2.0-85066150377
dc.identifier.scopusqualityQ1
dc.identifier.startpage352en_US
dc.identifier.urihttps://doi.org/10.1016/j.colsurfa.2019.05.013
dc.identifier.urihttps://hdl.handle.net/20.500.12587/7712
dc.identifier.volume575en_US
dc.identifier.wosWOS:000471655500040
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier Science Bven_US
dc.relation.ispartofColloids And Surfaces A-Physicochemical And Engineering Aspects
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDual stimuli-sensitive systemsen_US
dc.subjectMicroparticlesen_US
dc.subjectAlginateen_US
dc.subjectPoly(N,N-diethyl acrylamide)en_US
dc.subject5-Fluorouracilen_US
dc.titleDevelopment and characterization of dual sensitive poly(N,N-diethyl acrylamide) grafted alginate microparticlesen_US
dc.typeArticle

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