Chemical constituents and their bioactivities from truffle Hysterangium inflatum

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dc.authoridTel-Cayan, Gulsen/0000-0002-1916-7391
dc.authoridDURU, Mehmet Emin/0000-0001-7252-4880
dc.authoridKucukaydin, Selcuk/0000-0001-8538-6528
dc.contributor.authorTas, Meltem
dc.contributor.authorKucukaydin, Selcuk
dc.contributor.authorTel-Cayan, Gulsen
dc.contributor.authorDuru, Mehmet Emin
dc.contributor.authorOzturk, Mehmet
dc.contributor.authorTurk, Mustafa
dc.date.accessioned2025-01-21T16:36:33Z
dc.date.available2025-01-21T16:36:33Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractHysterangium inflatum is a truffle that grows naturally in the roots of Eucalyptus sp. and is distributed along the Mediterranean and Aegean coasts. Chemical investigation of the H. inflatum enabled to isolate of a new cerebroside, hysteroside (1), and seven known compounds namely, psyllic acid (2), brassicasterol (3), ergosterol (4), ergosterol d (5), ergosterol peroxide (6), ergosta-7,9,22-triene-3-O-beta-d-glucoside (7) and mannitol (8). IR, NMR, MS techniques were used for structural elucidation and supported with literature data. Antioxidant, cholinesterase, urease, and tyrosinase inhibitory and cytotoxic activities on MCF-7 breast, H-1299 lung cancer cells, and murine fibroblast (L929) non-cancerous cells of extracts and isolated compounds from H. inflatum were analyzed. All the isolated compounds, except compounds 2 and 8, displayed considerable cytotoxic activities against MCF-7 and H-1299 cancer cells. Compounds 1 (IC50: 18.11 mu g/mL) and 5 (IC50: 24.93 mu g/mL) were the most effective against MCF-7, while compounds 6 (IC50: 27.61 mu g/mL), 1 (IC50: 36.20 mu g/mL) and 5 (IC50: 38.62 mu g/mL) showed most potent toxicity against H-1299 and the extracts and compounds have no toxic effect on L929. Among the extracts, the methanol extract displayed the best antioxidant activity in all assays. Compound 1 exhibited highest enzyme inhibition activities with value of 58.71%, 52.84%, 45.37%, and 35.63%, against urease, tyrosinase, butrylcholinesterase (BChE), and acetylcholinesterase (AChE) enzymes at 100 mu g/mL concentration, among the isolated compounds. These results support that H. inflatum is a steroid-rich truffle and might be a potential source, especially for ergostane type steroids.
dc.description.sponsorshipScientific and Technological Research Council of Turkey [TUBITAK-114Z644]; Mugla Sitki Kocman University Research Fund [MUBAP 16/132]
dc.description.sponsorshipThis study is a part of M.T.'s Master's thesis. The authors are deeply indebted to The Scientific and Technological Research Council of Turkey (Project Number: TUBITAK-114Z644) for the opportunity to carry out this research. The Mugla Sitki Kocman University Research Fund is also acknowledged under Project Number (MUBAP 16/132).
dc.identifier.doi10.1007/s11694-021-00993-9
dc.identifier.endpage4189
dc.identifier.issn2193-4126
dc.identifier.issn2193-4134
dc.identifier.issue5
dc.identifier.scopus2-s2.0-85107565751
dc.identifier.scopusqualityQ1
dc.identifier.startpage4181
dc.identifier.urihttps://doi.org/10.1007/s11694-021-00993-9
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24330
dc.identifier.volume15
dc.identifier.wosWOS:000659034200001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofJournal of Food Measurement and Characterization
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectHysterangium inflatum; Truffle; Cytotoxicity; Bioactive compounds; Hysteroside; Biological activity
dc.titleChemical constituents and their bioactivities from truffle Hysterangium inflatum
dc.typeArticle

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