The Role Of Cholesterol On The Pressure Sensing Ability Of Kidneys In Rats

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dc.contributor.authorEdremitlioglu, Mustafa
dc.contributor.authorÖner, Gülsen
dc.date.accessioned2020-06-25T15:13:19Z
dc.date.available2020-06-25T15:13:19Z
dc.date.issued2003
dc.departmentKırıkkale Üniversitesi
dc.description.abstractWe studied the effect of hypercholesterolemia on the pressure-sensing and regulating ability of the kidneys, using an acute hemorrhage model to provide 40% and 60% reduction in the blood pressure of hypercholesterolemic and control rats. The control group (n = 22) was fed a normal rat pellet diet and tap water; the experimental group (n = 22) received a diet containing 2% cholesterol/0.2% thaurocholate. Half the animals were subjected to 6 mL/kg bw and the others to 12 mL/kg bw of bleeding for 1 min. Blood pressure recording and proper samplings were done before bleeding and during the 20 min posthemorrhagic period for analysis. Despite a finding of hypercholesterolemia in the experimental group, kidney cholesterol content as well as its function remained unchanged. Following an initial 40% decrease in rats bled 6 mL/kg bw, 20 min later the mean blood pressure returned to 90% of its initial value in control rats and to 70% of its basal level in hypercholesterolemic rats. A similar delay in pressure normalization occurred in rats subjected to 12 mL/kg of bleeding. Plasma renin activity remained unaffected. We conclude that dietary hypercholesterolemia delays the normalization of blood pressure after hemorrhage without affecting the sensing ability of kidneys, and that the kidneys are less sensitive than other organs to plasma cholesterol levels. © 2011 by Walter de Gruyter GmbH & Co. All rights reserved.en_US
dc.description.sponsorshipThis work was Foundation grant no:en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1515/JBCPP.2003.14.4.345
dc.identifier.endpage358en_US
dc.identifier.issn07926855
dc.identifier.issue4en_US
dc.identifier.pmid15198306
dc.identifier.scopus2-s2.0-19244384072
dc.identifier.scopusqualityQ3
dc.identifier.startpage345en_US
dc.identifier.urihttps://doi.org/10.1515/JBCPP.2003.14.4.345
dc.identifier.urihttps://hdl.handle.net/20.500.12587/1735
dc.identifier.volume14en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.relation.ispartofJournal of Basic and Clinical Physiology and Pharmacology
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectblood pressureen_US
dc.subjecthemorrhagic hypotensionen_US
dc.subjecthypercholesterolemiaen_US
dc.subjectkidney functionsen_US
dc.subjectplasma activityen_US
dc.titleThe Role Of Cholesterol On The Pressure Sensing Ability Of Kidneys In Ratsen_US
dc.typeArticle

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