Association Between TP53 Gene Polymorphism and Obesity

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dc.contributor.authorCi?Han, Mehmethan
dc.contributor.authorBuluş, Hakan
dc.contributor.authorDi?Ri?Can, Onur
dc.contributor.authorOğuztüzün, Serpil
dc.contributor.authorÖztürk, Doğan
dc.contributor.authorÜnsal, Abdulkadir
dc.contributor.authorAda, Ahmet Oğuz
dc.date.accessioned2025-01-21T16:26:54Z
dc.date.available2025-01-21T16:26:54Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObesity is a chronic disorder with increasing prevalence worldwide and occurs when energy intake is greater than energy expenditure. Obesity is one of the factors that cause oxidative stress and arises from an imbalance between the reactive oxygen species (ROS) and the cell's antioxidant defense system. Increasing ROS in obesity, influencing the hypothalamic neurons, affects hunger and satiety control, so correspondingly on body weight control. When ROS amount increases, through DNA, protein and lipid oxidation, cell damage, necrosis, and apoptosis take place. Tumor protein p53, the guardian of the genome, is responsible for the regulation of genes involved in apoptosis as well as energy generating metabolic pathways. In our study, we investigated the TP53 (Arg72Pro) polymorphism in 151 patients diagnosed with obesity. TP53 mutation (rs1042522) was determined by real-time PCR. In 8 patients, the TP53 mutation was identified as carrying heterozygous (Arg72Pro) and in 143 patients carrying homozygous (wild type) (Arg72Arg). No individual with a homozygous mutant (Pro72Pro) genotype was found in the studied group. Associations between TP53 genotypes and clinical obesity parameters such as body mass index, thyroid stimulating hormon, glucose, postprandial blood sugar, triglyceride and cholesterol levels were compared statistically. According to the results of statistical analysis, it was observed that TP53 polymorphism was associated with insulin level. Genotype frequencies were also compared with previous studies performed in control populations and found to be different. This study shows that there may be a relationship between TP53(Arg72Pro) polymorphism and obesity. © 2021 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.
dc.identifier.endpage288
dc.identifier.issn1300-4182
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85122758854
dc.identifier.scopusqualityQ4
dc.identifier.startpage279
dc.identifier.trdizinid513071
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/513071
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23230
dc.identifier.volume46
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherSociety of Pharmaceutical Sciences of Ankara (FABAD)
dc.relation.ispartofFabad Journal of Pharmaceutical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectObesity; Oxidative stress; Polymorphism; TP53
dc.titleAssociation Between TP53 Gene Polymorphism and Obesity
dc.typeArticle

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