Bioequivalence of three florfenicol preparations in broilers

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dc.contributor.authorEkici H.
dc.contributor.authorYarsan E.
dc.date.accessioned2020-06-25T15:17:24Z
dc.date.available2020-06-25T15:17:24Z
dc.date.issued2014
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThis study was aimed to determine the bioequivalence of three different preparations of florfenicol using non-drugged broiler chickens. A total of 28 broiler chickens aging 30-day were divided into four equal groups; these were Group I, II, III, and IV. The birds of Group I (for effective substance) were given intravenous (i.v.) administration of florfenicol dosed at 40 mg/kg body weight (b.wt.). The birds of Group II (for reference drug), Group III (for test-1 drug), and Group IV (for test-2 drug) received florfenicol preparations with water (dosed at 40 mg/kg b.wt.) through intracrop administration. Blood samples were collected periodically from the birds of all four groups, and blood plasma was separated. Levels of florfenicol and its metabolite (florfenicol amine) in the plasma were measured by High Performance Liquid Chromatography (HPLC). In this study, the limit of detection (LOD) for florfenicol and florfenicol amine were recorded as 0.017 and 0.78 ?g/mL, respectively. On the other hand, the recovery of florfenicol and florfenicol amine were 83.4-84.6 and 82.2-83.8%, respectively. Based on the values of area under the curve (AUC), maximum concentration (Cmax), and time to maximum concentration (Tmax), test-1 drug was found to be acceptable, whereas test-2 drug was remained below the acceptable limits (80-125%) of AUC and Cmax. Thus, it was concluded that test-1 drug was bioequivalent as compared to the reference drug.en_US
dc.identifier.doi10.5455/javar.2014.a28
dc.identifier.endpage168en_US
dc.identifier.issn23117710
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85026736402
dc.identifier.scopusqualityQ2
dc.identifier.startpage163en_US
dc.identifier.urihttps://doi.org/10.5455/javar.2014.a28
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2351
dc.identifier.volume1en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherNetwork for the Veterinarians of Bangladeshen_US
dc.relation.ispartofJournal of Advanced Veterinary and Animal Research
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectBioequivalenceen_US
dc.subjectBroiler chickenen_US
dc.subjectFlorfenicolen_US
dc.subjectFlorfenicol amineen_US
dc.subjectPharmacokineticen_US
dc.titleBioequivalence of three florfenicol preparations in broilersen_US
dc.typeArticle

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