PROGESTERONE INCREASES THE ISCHEMIC DAMAGE IN MALE RATS WITH CEREBRAL ISCHEMIA REPERFUSION INJURY

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dc.contributor.authorÖğden, Mustafa
dc.contributor.authorBakar, Bülent
dc.contributor.authorAltunkaya, Canan
dc.contributor.authorDağlı, Ahmet Turan
dc.contributor.authorÖzdemir, Alemiddin
dc.contributor.authorÖzveren, Mehmet Faik
dc.date.accessioned2025-01-21T16:19:24Z
dc.date.available2025-01-21T16:19:24Z
dc.date.issued2019
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: In the current literature, there are few acceptedpharmacological treatment methods for acute ischemic stroke.This study was conducted to investigate the effects ofprogesterone on transient ischemia / reperfusion injury in malerats.Material and Methods: A total of 25 Wistar albino male andyoung rats were divided into 5 groups called Control group,acute stage groups (Sham-A and PRG-A), and chronic stagegroups (Sham-C and PRG-C), randomly and their internalcarotid arteries were compressed using temporary aneurysmclips for 30 minutes. At 4 hours after removal of the clips,progesterone was injected to the animals of the PRG-A andPRG-C group via intraperitoneal route. After sacrifice of allanimals, pyknotic and necrotic neuronal cells were counted inhippocampal cornu amnonis (CA)1, CA2, CA3 and parietalcortical regions, histopathologically. Tissue interleukin (IL)-6,IL-10, caspase-3, and hypoxia-inducible factor-1 (HIF1) geneexpression levels were evaluated using real time polymerasechain reaction assay.Results: Histopathological and biochemical findings revealedthat progesterone has no healing effects on ischaemic neuronaltissue damage in either acute or chronic period. Moreover,progesterone was found to significantly increase symptoms ofischaemia in both acute and chronic periods compared tohealthy control group and even compared to Sham groups whereI/R injury was applied and no experimental agent wasadministered.Conclusion: At the end of this study, it was thought thatprogesterone had no therapeutic effect on cerebral ischemia /reperfusion injury in male sex rats and it could lead to increase itfurther, unfortunately.
dc.identifier.doi10.24938/kutfd.531788
dc.identifier.endpage194
dc.identifier.issn2148-9645
dc.identifier.issue2
dc.identifier.startpage183
dc.identifier.trdizinid415113
dc.identifier.urihttps://doi.org/10.24938/kutfd.531788
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/415113
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23070
dc.identifier.volume21
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofKırıkkale Üniversitesi Tıp Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectTıbbi Araştırmalar Deneysel
dc.subjectEndokrinoloji ve Metabolizma
dc.subjectNörolojik Bilimler
dc.subjectFizyoloji
dc.titlePROGESTERONE INCREASES THE ISCHEMIC DAMAGE IN MALE RATS WITH CEREBRAL ISCHEMIA REPERFUSION INJURY
dc.typeArticle

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