Effects of Dexmedetomidine Administered Through Different Routes on Kidney Tissue in Rats with Spinal Cord Ischaemia–Reperfusion Injury

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dc.contributor.authorŞengel, Necmiye
dc.contributor.authorKöksal, Zeynep
dc.contributor.authorDursun, Ali Doğan
dc.contributor.authorArslan, Mustafa
dc.contributor.authorKavutçu, Mustafa
dc.contributor.authorKurtipek, Ömer
dc.contributor.authorSezen, Şaban Cem
dc.date.accessioned2025-01-21T16:27:31Z
dc.date.available2025-01-21T16:27:31Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: Ischaemia–reperfusion (IR) injury, which can be encountered during surgical procedures involving the abdominal aorta, is a complex process that affects distant organs, such as the heart, liver, kidney, and lungs, as well as the lower extremities. In this study, we aimed to contribute to the limited literature by investigating the protective effect of dexmedetomidine, which was administered through different routes, on kidney tissue in rats with spinal cord IR injury. Methods: A total of 30 rats were randomly divided into five groups: control (C group), IR (IR group), IR-intraperitoneal dexmedetomidine (IRIPD group), IR-intrathecal dexmedetomidine (IRITD group), and IR-intravenous dexmedetomidine (IRIVD group). The spinal cord IR model was established. Dexmedetomidine was administered at doses of 100 µg/kg intraperitoneally, 3 µg/ kg intrathecally, and 9 µg/kg intravenously. Histopathologic parameters in kidney tissue samples taken at the end of the reperfusion period and biochemical parameters in serum were evaluated. Results: When examined histopathologically, tubular dilatation was found to be significantly reduced in the IRIVD, IRITD, and IRIPD groups compared with the IR group (p = 0.012, all). Vascular vacuolization and hypertrophy were significantly decreased in the IRIVD, IRITD, and IRIPD groups compared with the IR group (p = 0.006, all). Tubular cell degeneration and necrosis were significantly reduced in the IRIVD, IRITD, and IRIPD groups compared with the IR group (p = 0.008, p = 0.08, and p = 0.030, respectively). Lymphocyte infiltration was significantly decreased in the IRIVD and IRITD groups compared with the IR group (p = 0.006 and p = 0.06, respectively). Conclusion: It was observed that dexmedetomidine administered by different routes improved the damage caused by IR in kidney histopathology. We think that the renoprotective effects of dexmedetomidine administered intravenously and intrathecally before IR in rats are greater. © 2022 Şengel et al.
dc.identifier.doi10.2147/DDDT.S361618
dc.identifier.endpage2239
dc.identifier.issn1177-8881
dc.identifier.pmid35860522
dc.identifier.scopus2-s2.0-85134164291
dc.identifier.scopusqualityQ1
dc.identifier.startpage2229
dc.identifier.urihttps://doi.org/10.2147/DDDT.S361618
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23340
dc.identifier.volume16
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherDove Medical Press Ltd
dc.relation.ispartofDrug Design, Development and Therapy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectdexmedetomidine; intrathecal; intravenous; ischaemia–reperfusion; rat
dc.titleEffects of Dexmedetomidine Administered Through Different Routes on Kidney Tissue in Rats with Spinal Cord Ischaemia–Reperfusion Injury
dc.typeArticle

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