Heparin-coated poly(hydroxyethyl methacrylate/albumin) hydrogel networks: In vitro hemocompatibility evaluation for vascular biomaterials

Basit Öğe Kaydı
dc.contributor.authorBayramoglu, Gülay
dc.contributor.authorYilmaz, Meltem
dc.contributor.authorBatislam, Ertan
dc.contributor.authorArica, M. Yakup
dc.date.accessioned2020-06-25T17:44:29Z
dc.date.available2020-06-25T17:44:29Z
dc.date.issued2008
dc.departmentKırıkkale Üniversitesi
dc.descriptionBatislam, Ertan/0000-0002-7493-4573
dc.description.abstractHuman serum albumin (AL) containing poly(hydroxyethyl methacrylate) (pHEMA; in tube form with an inner diameter of 6 mm) was synthesized for blood-contacting hydrogel networks via UV-initiated photopolymerization. at 25 degrees C. Tensile and breaking tests of pHEMA and pHEMA-AL-1-4 hydrogel networks were studied at their equilibrium water content. The mechanical strength of the hydrogel networks was found to be lowered by an increase in the ratio of AL in the polymer networks. To increase the blood compatibility and prevent thrombus formation, the surface of the pHEMA and pHEMA-AL-3 hydrogel compositions were coated with heparin (HEP). Contact-angle studies showed that the polarities (%) of the pHEMA-AL-3 and pHEMA-AL-3-HEP hydrogel networks were significantly increased in comparison with that of pure pHEMA. The fibrinogen adsorption and platelet adhesion were also reduced after the incorporation of AL and HEP into/onto hydrogel networks in comparison with the pure pHEMA control. Blood compatibility tests of the prepared hydrogel networks, which were intended to be used as blood-contacting materials, were examined with various parameters, such as the hemolytic activity, prothrombin time, activated thromboplastin time, and loss of blood cells in blood. (C) 2008 Wiley Periodicals, Inc.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1002/app.28062
dc.identifier.endpage757en_US
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-47949102427
dc.identifier.scopusqualityQ2
dc.identifier.startpage749en_US
dc.identifier.urihttps://doi.org/10.1002/app.28062
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4121
dc.identifier.volume109en_US
dc.identifier.wosWOS:000256267200008
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Applied Polymer Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectbiocompatibilityen_US
dc.subjectbiomaterialsen_US
dc.subjectcoatingsen_US
dc.subjecthydrogelsen_US
dc.subjectproteinsen_US
dc.titleHeparin-coated poly(hydroxyethyl methacrylate/albumin) hydrogel networks: In vitro hemocompatibility evaluation for vascular biomaterialsen_US
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
Heparin-coated poly(hydroxyethyl methacrylate albumin) hydrogel networks In vitro hemocompatibility evaluation for vascular biomaterials.pdf
Boyut:
214.72 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin/Full Text
İndir

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu
Makale Koleksiyonu
Makale Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu