The effects of N-methyl-D-aspartate antagonist MK-801 and adenosine receptor agonists on mononeuropathic rats

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dc.contributor.authorApan, Alparslan
dc.date.accessioned2020-06-25T15:13:12Z
dc.date.available2020-06-25T15:13:12Z
dc.date.issued2001
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe present study was to determine whether administration of adenosine A1 receptor agonist cyclohexyladenosine (CHA) and adenosine A1/A2 receptor agonist 5?N-ethylcarboxamidoadenosine (NECA) and N-methyl-D-aspartate antagonist MK-801 on thermal nociception in rat chronic constriction injury model. 48 Sprague Dawley male rats weighting 185-225 g were included to the study. The right common sciatic nerves were ligated loosely with four 4/0 chromic gut under barbiturate anesthesia. Drugs were administered and nociceptive test performed for four days after 7 days' recovery. NECA, CHA and MK-801 were administered two times at doses of 0.1 mg/kg, 1 mg/kg, and 1 mg/kg respectively. The doses were inclined to the half while both of two drug were given. Noci-ceptive threshold was determined by hot plate test at 46°C during treatment period. Time to jumping or licking of the limb on the operated site was determined. The thermal test results of MK-801 given animals were demonstrated antinociception initially, but declined to the baseline through the treatment period. Antiallodynic effects reduced on CHA group when combined with MK-801. The nociceptive treshold of NECA treated animals were as the same with NECA+MK-801. Antiallodynic effects of NECA were partly due to its motor blocking properties. The results we obtained appear to be disappointing while both of two class of drugs given systemically acting as glutamate antagonist. The future studies may be directed to the other routes which may act synergistically.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.endpage501en_US
dc.identifier.issn10165150
dc.identifier.issue9en_US
dc.identifier.scopus2-s2.0-0035698208
dc.identifier.scopusqualityN/A
dc.identifier.startpage497en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12587/1657
dc.identifier.volume29en_US
dc.indekslendigikaynakScopus
dc.language.isotr
dc.relation.ispartofTurk Anesteziyoloji ve Reanimasyon
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject5? N-ethyl carboxamidoadenosineen_US
dc.subjectCyclohexyladenosineen_US
dc.subjectMK-801en_US
dc.subjectMononeuropathyen_US
dc.subjectN-methyl-D-aspartateen_US
dc.titleThe effects of N-methyl-D-aspartate antagonist MK-801 and adenosine receptor agonists on mononeuropathic ratsen_US
dc.title.alternativeMononöropatik ratlarda N-methyl-D-aspartate antagonisti MK-801 ve adenozin reseptör agonistlerinin etkilerien_US
dc.typeArticle

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