Low-molecular-weight heparin-conjugated liposomes with improved stability and hemocompatibility

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dc.contributor.authorKöse G.T.
dc.contributor.authorArica M.Y.
dc.contributor.authorHasirci V.
dc.date.accessioned2020-06-25T15:13:10Z
dc.date.available2020-06-25T15:13:10Z
dc.date.issued1998
dc.departmentKırıkkale Üniversitesi
dc.description.abstractMultilamellar vesicles (MLV) containing phosphatidyl choline (PC), cholestrol (CHOL), and stearylamine (SA) in the molar ratio of 7:2:0.2 were prepared by the thin film hydration method. Low-molecular-weight heparin (LMWH, MW: 3000) was conjugated with the MLV using carbodiimide (EDC). Infrared, Raman, and nuclear magnetic resonance spectra and DSC of each sample (MLV, LMWH, and MLV-LMWH) were obtained, enabling the authors to determine the chemical changes that occurred in the MLV structure at the end of the conjugation step. In addition, the changes in the chemical structures of the conjugated samples were revealed by the use of elemental analysis. Particle size analysis was used to determine the difference between the sizes of MLV and MLV-LMWH. In order to study the effect of LMWH on the behavior of MLV-LMWH in blood, osmotic fragility (in saline and plasma), hemolytic activity, and plasma recalcification time tests were carried out. These tests showed that it was possible to construct liposomes that would not induce reactions in the blood and would have potentially longer half-lives in the circulation.en_US
dc.identifier.doi10.3109/10717549809065756
dc.identifier.endpage264en_US
dc.identifier.issn10717544
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-2442764678
dc.identifier.scopusqualityQ1
dc.identifier.startpage257en_US
dc.identifier.urihttps://doi.org/10.3109/10717549809065756
dc.identifier.urihttps://hdl.handle.net/20.500.12587/1623
dc.identifier.volume5en_US
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherTaylor and Francis Inc.en_US
dc.relation.ispartofDrug Delivery: Journal of Delivery and Targeting of Therapeutic Agents
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectConjugationen_US
dc.subjectHemocompatibilityen_US
dc.subjectLiposome Stabilityen_US
dc.subjectLow Molecular Weight Heparinen_US
dc.subjectMultilamellar Liposomeen_US
dc.titleLow-molecular-weight heparin-conjugated liposomes with improved stability and hemocompatibilityen_US
dc.typeArticle

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