Efficacy of amitriptyline in the treatment of subjective tinnitus

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dc.contributor.authorBayar, N.
dc.contributor.authorBöke, B.
dc.contributor.authorTuran, E.
dc.contributor.authorBelgin, E.
dc.date.accessioned2020-06-25T17:34:48Z
dc.date.available2020-06-25T17:34:48Z
dc.date.issued2001
dc.departmentKırıkkale Üniversitesi
dc.description.abstractWe investigated the effect of amitriptyline, a tricyclic antidepressant, on patients with subjective tinnitus. The study group consisted of 37 adult patients admitted to the Ear, Nose, and Throat and Audiology Department of Hacettepe University. The amitriptyline group consisted of 20 patients and the placebo group consisted of 17 patients. All of the patients were evaluated using a questionnaire, audiologic evaluation, high-frequency audiometry, impedancemetric tests, auditory brainstem response, tinnitus frequency, and loudness matching assessed by audiometric methods at the beginning and end of the study. The patients in the amitriptyline group received 50 mg/day amitriptyline in the first week and 100 mg/day for the following 5 weeks. In the placebo group, the patients received tablets consisting of lactose starch for 6 weeks, with a dosage of 1 tablet/day. The subjective complaints of the patients in the amitriptyline group decreased, and the "present" symptoms resulted in fewer complaints. The severity of tinnitus decreased in the amitriptyline group by means of subjective and audiometric methods. In the placebo group, no significant change was observed. The success of treatment was 95% in the amitriptyline group and 12% in the placebo group. Amitriptyline therapy was concluded to be effective.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.2310/7070.2001.19597
dc.identifier.endpage303en_US
dc.identifier.issn0381-6605
dc.identifier.issue5en_US
dc.identifier.pmid11771024
dc.identifier.startpage300en_US
dc.identifier.urihttps://doi.org/10.2310/7070.2001.19597
dc.identifier.urihttps://hdl.handle.net/20.500.12587/2896
dc.identifier.volume30en_US
dc.identifier.wosWOS:000171541900009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherB C Decker Incen_US
dc.relation.ispartofJournal Of Otolaryngology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectamitriptylineen_US
dc.subjecttinnitusen_US
dc.subjecttricyclic antidepressantsen_US
dc.titleEfficacy of amitriptyline in the treatment of subjective tinnitusen_US
dc.typeArticle

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