Effect of curcumin on erythrocyte deformability in mice with limb ischemia-reperfusion injury

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dc.contributor.authorArslan, Gökhan
dc.contributor.authorKartal, Hakan
dc.contributor.authorÇomu, Faruk Metin
dc.contributor.authorÇetin, Erdem
dc.contributor.authorSicim, Hüseyin
dc.contributor.authorDemirdaş, Ertan
dc.contributor.authorGünay, Celalettin
dc.date.accessioned2025-01-21T16:27:21Z
dc.date.available2025-01-21T16:27:21Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectives: This study aims to examine the impact of curcumin on erythrocyte deformability in a mouse model that can be used for short-term ischemia/reperfusion (IR) injury. Materials and methods: A total of 30 mice were divided into five groups of six animals in each. The mice were subjected to unilateral hind limb ischemia on the femoral vessels for 2 h. Reperfusion was achieved for the next 2 h. Curcumin (100 mg·kg-1) was administered intraperitoneally (CUR and IR/CUR groups). The mice were euthanized by intraperitoneal administration of ketamine (100 mg·kg-1) and blood was drawn from the heart. A constant flow filter system was used to assess erythrocyte deformability. Results: There was a statistically significant difference in the mean deformability index among the groups. The IR group (2.1±0.3) significantly higher than the mean of control group (1.6±0.2), CUR group (1.6±0.1) and DMSO group (1.6±0.2). The deformability index values of the IR/CUR group approach the control group through the application of the curcumin (1.8±0.2). Conclusion: Our study showed negative effects of IR on erythrocyte deformability in mice. Also, curcumin had positive effects by reversing the undesirable effects of IR. © 2022 Turkish National Vascular and Endovascular Surgery Society. All rights reserved.
dc.identifier.doi10.9739/tjvs.2022.1104
dc.identifier.endpage38
dc.identifier.issn2667-5080
dc.identifier.issue1
dc.identifier.scopus2-s2.0-85176943133
dc.identifier.scopusqualityQ4
dc.identifier.startpage33
dc.identifier.trdizinid528993
dc.identifier.urihttps://doi.org/10.9739/tjvs.2022.1104
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/528993
dc.identifier.urihttps://hdl.handle.net/20.500.12587/23327
dc.identifier.volume31
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTurkish National Vascular and Endovascular Surgery Society
dc.relation.ispartofTurkish Journal of Vascular Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectCurcumin; erythrocyte deformability; ischemia-reperfusion
dc.titleEffect of curcumin on erythrocyte deformability in mice with limb ischemia-reperfusion injury
dc.typeArticle

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