Growth, tolerance and safety outcomes with use of an extensively hydrolyzed casein-based formula in infants with cow's milk protein allergy

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dc.authoridUsta, Merve/0000-0002-5086-6270
dc.authoridDOGAN, YASAR/0000-0001-9738-9611
dc.authoridAZKUR, DILEK/0000-0002-4396-9087
dc.authoridGumus, Meltem/0000-0002-9257-6597
dc.contributor.authorKansu, Aydan
dc.contributor.authorUrganci, Nafiye
dc.contributor.authorBukulmez, Aysegul
dc.contributor.authorKutluk, Gunsel
dc.contributor.authorTaskin, Didem Gulcu
dc.contributor.authorKeskin, Lutfiye Sahin
dc.contributor.authorIgde, Mahir
dc.date.accessioned2025-01-21T16:41:22Z
dc.date.available2025-01-21T16:41:22Z
dc.date.issued2023
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjectiveTo evaluate growth, tolerance and safety outcomes with use of an extensively hydrolyzed casein-based formula (eHCF) in infants with cow's milk protein allergy (CMPA). MethodsA total of 226 infants (mean & PLUSMN; SD age: 106.5 & PLUSMN; 39.5 days, 52.7% were girls) with CMPA who received eHCF comprising at least half of the daily dietary intake were included. Data on anthropometrics [weight for age (WFA), length for age (LFA) and weight for length (WFL) z-scores] were recorded at baseline (visit 1), while data on infant feeding and stool records, anthropometrics and Infant Feeding and Stool Patterns and Formula Satisfaction Questionnaires were recorded at visit 2 (on Days 15 & PLUSMN; 5) and visit 3 (on Days 30 & PLUSMN; 5). ResultsFrom baseline to visit 2 and visit 3, WFA z-scores (from -0.60 & PLUSMN; 1.13 to -0.54 & PLUSMN; 1.09 at visit 2, and to -0.44 & PLUSMN; 1.05 at visit 3, p < 0.001) and WFL z-scores (from -0.80 & PLUSMN; 1.30 to -0.71 & PLUSMN; 1.22 at visit 2, and to -0.64 & PLUSMN; 1.13 at visit 3, p = 0.002) were significantly increased. At least half of infants never experienced irritability or feeding refusal (55.7%) and spit-up after feeding (50.2%). The majority of mothers were satisfied with the study formula (93.2%), and wished to continue using it (92.2%). ConclusionsIn conclusion, eHCF was well-accepted and tolerated by an intended use population of infants & LE; 6 months of age with CMPA and enabled adequate volume consumption and improved growth indices within 30 days of utilization alongside a favorable gastrointestinal tolerance and a high level of parental satisfaction.
dc.description.sponsorshipAbbott Nutrition Turkey
dc.description.sponsorshipThis work was supported by Abbott Nutrition Turkey.
dc.identifier.doi10.3389/fped.2023.1230905
dc.identifier.issn2296-2360
dc.identifier.pmid37601126
dc.identifier.urihttps://doi.org/10.3389/fped.2023.1230905
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24877
dc.identifier.volume11
dc.identifier.wosWOS:001047492100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherFrontiers Media Sa
dc.relation.ispartofFrontiers In Pediatrics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectcow's milk protein allergy; extensively hydrolyzed casein-based formula; growth indices; gastrointestinal intolerance; stool patterns; parental satisfaction
dc.titleGrowth, tolerance and safety outcomes with use of an extensively hydrolyzed casein-based formula in infants with cow's milk protein allergy
dc.typeArticle

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