Comparison of brain F-18 FDG PET/MRI with PET/CT imaging in pediatric patients

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dc.authoridBeytur, Fatih/0000-0001-6636-9749
dc.authoridAkgun, Mehmet Yigit/0000-0003-1342-7663
dc.authoridBAYDILI, Kursad Nuri/0000-0002-2785-0406
dc.contributor.authorSager, Gunes
dc.contributor.authorAkgun, Elife
dc.contributor.authorAbuqbeitah, Muhammed
dc.contributor.authorUslu, Lebriz
dc.contributor.authorAsa, Sertac
dc.contributor.authorAkgun, Mehmet Yigit
dc.contributor.authorBeytur, Fatih
dc.date.accessioned2025-01-21T16:36:46Z
dc.date.available2025-01-21T16:36:46Z
dc.date.issued2021
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground: Standardized uptake values (SUVs) are important indexes for evaluating the accuracy of disease diagnoses achieved via fluoro-18 deoxyglucose (F-18 FDG) positron emission tomography/computed tomography (PET/CT) and positron emission tomography/magnetic resonance imaging (PET/MRI). The purpose of this study is to describe normal cerebral FDG uptake in the pediatric population and compare SUVmax/mean results for brain images obtained from PET/CT and PET/MRI in neurologically healthy pediatric examinees. Methods: This study included 20 patients who were < 18 years of age and were without intracranial malignancy and/or brain disorders. Patients underwent either PET/CT imaging (n = 10) or PET/MRI imaging (n = 10) after 70-80 min of F-18 FDG injection. The SUVmax and SUVmean for various brain regions were calculated and compared between sides and imaging modalities using with appropriate statistical tests. Results: The median SUVmax/SUVmean values of the right-sided frontal, parietal, temporal, and occipital lobes were 8.63/ 6.18, 8.85 / 6.97, 6.88 / 4.99, and 11.06 / 7.02 in PET/CT, respectively, and 11.45 / 8.59, 10.16 / 8.47, 8.82 / 6.6, and 11.71 / 8.25 in PET/MRI, respectively. The median SUVmax/SUVmean values of the leftsided frontal, parietal, temporal, and occipital lobes were 9.05 / 6.86, 8.03 / 6.62, 6.49 / 4.77, and 10.6 / 7.73 in PET/CT, respectively, and 10.7 / 8.16, 11.06 / 7.88, 8.13 / 6.09, and 10.96 / 9.22 in PET/MRI, respectively. Conclusions: These results showed that there was no statistically significant difference in SUVs values between the two brain imaging modalities except from SUVmax value of left-sided parietal lobe and no asymmetric radiopharmaceutical uptake between the left and right brain regions or cerebellums in each modality, suggested that in brain imaging, PET/MRI can be used reliably instead of PET/CT.
dc.identifier.doi10.1016/j.clineuro.2021.106669
dc.identifier.issn0303-8467
dc.identifier.issn1872-6968
dc.identifier.pmid33984753
dc.identifier.urihttps://doi.org/10.1016/j.clineuro.2021.106669
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24381
dc.identifier.volume206
dc.identifier.wosWOS:000659840900015
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofClinical Neurology and Neurosurgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.subjectFDG; PET; CT; PET; MRI; Brain; Pediatric patients
dc.titleComparison of brain F-18 FDG PET/MRI with PET/CT imaging in pediatric patients
dc.typeArticle

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