Synthesis and characterization of pH- and temperature-sensitive materials based on alginate and poly(N-isopropylacrylamide/acrylic acid) for drug delivery

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dc.contributor.authorIsiklan, Nuran
dc.contributor.authorKucukbalci, Gulucan
dc.date.accessioned2020-06-25T18:16:38Z
dc.date.available2020-06-25T18:16:38Z
dc.date.issued2016
dc.departmentKırıkkale Üniversitesi
dc.description.abstractThe significant developments in the field of polymer have advanced the synthesis of polymer-based materials and have expanded their use in a wide variety of applications. Today, polymers can be designed to change their properties in response to a single stimulus or multiple stimuli. Such types of polymers are called stimuli-sensitive or stimuli-responsive polymers, and have been utilized for controlled release in the field of biomedicine. Herein, we report the use of alginate (SA) based graft copolymer with poly(N-isopropylacrylamide) (PIPAAm) and poly(acrylic acid) (PAA) to synthesize dual stimuli-sensitive beads via microwave-assisted graft copolymerization method for controlled release of indomethacin (IND). It is demonstrated that the polymer beads composed of SA-g-PIPAAm/PAA are sensitive to pH and temperature. The structure of successfully prepared stimuli-sensitive beads by cross-linking via glutaraldehyde is characterized by FTIR, X-RD and SEM analysis.en_US
dc.description.sponsorshipKirikkale UniversityKirikkale University [2011/07]en_US
dc.description.sponsorshipThe authors are grateful to the Kirikkale University for financial support with the project number of 2011/07.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1007/s00289-015-1550-x
dc.identifier.endpage1342en_US
dc.identifier.issn0170-0839
dc.identifier.issn1436-2449
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-84946781237
dc.identifier.scopusqualityQ1
dc.identifier.startpage1321en_US
dc.identifier.urihttps://doi.org/10.1007/s00289-015-1550-x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/6583
dc.identifier.volume73en_US
dc.identifier.wosWOS:000374180000007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherSpringeren_US
dc.relation.ispartofPolymer Bulletin
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectStimuli-sensitive polymersen_US
dc.subjectGraft copolymerizationen_US
dc.subjectSodium alginateen_US
dc.subjectPoly(N-isopropylacrylamide)en_US
dc.subjectPoly(acrylic acid)en_US
dc.titleSynthesis and characterization of pH- and temperature-sensitive materials based on alginate and poly(N-isopropylacrylamide/acrylic acid) for drug deliveryen_US
dc.typeArticle

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