HLA-class 1 and class 2 antigens in Turkish patients with pemphigus

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dc.contributor.authorBirol, A
dc.contributor.authorAnadolu, RY
dc.contributor.authorTutkak, H
dc.contributor.authorGürgey, E
dc.date.accessioned2025-01-21T16:41:28Z
dc.date.available2025-01-21T16:41:28Z
dc.date.issued2002
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground Pemphigus is an autoimmune disease which is more frequently seen in certain ethnic groups such as Jews. It is thought that exogenous factors may induce pemphigus in genetically predisposed individuals. Recent reports on HLA antigens indicate an increased frequency of Herein we investigated the HILA-class II antigens particularly HLA-DR4 among Jewish patients. antigen frequencies of HLA-A, B, C, HLA-DR and DO in Turkish patients with pemphigus. Methods HLA class I and II antigens were typed by microdroplet lymphocyte cytotoxicity test in 33 patients with pemphigus and 100 healthy individuals. Results HLA-B35, B44, CW4, DR4, DR14, DQ8 and DQ4 antigens were significantly high in the study group whereas HLA-DR11, DQ7 and DQ2 antigens were high among the controls. The most striking differences were observed in HLA class II antigens. HLADR14-DQ8 and HLA B35-DR14 haplotypes were the most frequently observed ones in the study group. Conclusions We postulate that HLA-B35, B44, CW4, DR4, DR14, DQ4 and DQ8 antigens may be responsible for susceptibility to pemphigus while HLA-DR11, DQ7 and DQ2 antigens may have a protective role in the Turkish population.
dc.identifier.doi10.1046/j.1365-4362.2002.01370.x
dc.identifier.endpage83
dc.identifier.issn0011-9059
dc.identifier.issue2
dc.identifier.pmid11982641
dc.identifier.startpage79
dc.identifier.urihttps://doi.org/10.1046/j.1365-4362.2002.01370.x
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24894
dc.identifier.volume41
dc.identifier.wosWOS:000175881700004
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBlackwell Publishing Ltd
dc.relation.ispartofInternational Journal of Dermatology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20241229
dc.titleHLA-class 1 and class 2 antigens in Turkish patients with pemphigus
dc.typeArticle

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